72194-52-6

Basic information

• Product Name: PGLU-GLY-ARG P-NITROANILIDE HYDROCHLORID
• Synonyms: PGLU-GLY-ARG P-NITROANILIDE HYDROCHLORID;Pyroglu-gly-argp-nitroanilide
• CAS NO: 72194-52-6
• Molecular Formula: C19H27ClN8O6
• Molecular Weight: 498.92068
• Product Categories: Activity;Enzyme Substrates;Fluorogenic
• Mol File: 72194-52-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: PGLU-GLY-ARG P-NITROANILIDE HYDROCHLORID(CAS DataBase Reference)
• NIST Chemistry Reference: PGLU-GLY-ARG P-NITROANILIDE HYDROCHLORID(72194-52-6)
• EPA Substance Registry System: PGLU-GLY-ARG P-NITROANILIDE HYDROCHLORID(72194-52-6)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-63
• Safety Statements: 22-26-36/37/39-45
• WGK Germany: 3
• Hazardous Substances Data: 72194-52-6(Hazardous Substances Data)

Usage

Description

PGLU-GLY-ARG P-NITROANILIDE HYDROCHLORID is a chemical compound that comprises a peptide sequence (PGLU-GLY-ARG) and p-nitroanilide, a yellow crystalline substance with nitro functionality. It is a synthetic substrate used in biochemical and medical research for its role as a chromogenic substrate for trypsin-like serine proteases, such as thrombin and trypsin.

Uses

Used in Biochemical Research:
PGLU-GLY-ARG P-NITROANILIDE HYDROCHLORID is used as a chromogenic substrate for measuring the activity of trypsin-like serine proteases. It serves this purpose by allowing researchers to monitor the release of p-nitroaniline, a yellow compound, through enzyme assays, which can be quantified spectrophotometrically.
Used in Medical Research:
In the medical field, PGLU-GLY-ARG P-NITROANILIDE HYDROCHLORID is utilized for studying the activity of proteases, which are crucial in various physiological processes and disease mechanisms. Its application aids in understanding and diagnosing conditions related to protease activity, as well as in the development of therapeutic agents targeting these enzymes.
Used in Enzyme Assays:
PGLU-GLY-ARG P-NITROANILIDE HYDROCHLORID is used as a detection tool in enzyme assays designed to evaluate the functionality and concentration of specific proteases. The release of p-nitroaniline upon enzymatic action provides a measurable and quantifiable signal, facilitating the assessment of protease activity in both basic and clinical research settings.