721945-24-0Relevant academic research and scientific papers
Pd-Catalyzed Three-Component Reaction of Anilines, Ethyl Vinyl Ether, and Nitro-Paraffin: Assembly of β-Nitroamines
Ouyang, Lu,Zhan, Lingzhi,Li, Jianxiao,Zhang, Qiaoyu,Qi, Chaorong,Wu, Wanqing,Jiang, Huanfeng
, p. 550 - 553 (2018)
A novel palladium-catalyzed amination and nitration of ethyl vinyl ether for the construction of β-nitroamine derivatives under mild conditions has been developed. This transformation provides a new strategy for the installation of amino and nitro from aromatic amines and nitro-paraffin into alkenes. Morpholine resulted in the aza-Henry reaction, while DABCO led to the unexpected rearrangement.
Aza-Henry reactions on C-Alkyl substituted aldimines
Pelagalli, Alessia,Pellacani, Lucio,Scandozza, Elia,Fioravanti, Stefania
, (2016/07/07)
The reactivity of C-CH3 substituted N-protected aldimines in aza-Henry addition reactions was compared with that of the analogous trifluoromethylated compounds. C-Alkyl aldimines easily reacted with nitro alkanes under solvent-free conditions and in the absence of catalyst, despite being worse electrophiles than C-CF3 aldimines, they gave the aza-Henry addition only when ZrCl4 was added. The presence of a bulky group on the imine carbon deeply influenced the reactivity.
