721947-01-9Relevant academic research and scientific papers
Dynamic resolution of atropisomeric amides using proline-derived imidazolines and ephedrine-derived oxazolidines
Clayden, Jonathan,Lai, Lai Wah,Helliwell, Madeleine
, p. 4399 - 4412 (2007/10/03)
Condensation of atropisomeric tertiary 2-formyl naphthamides or 2-formyl benzamides with some chiral diamines and amino alcohols leads, via a dynamic resolution process, to single atropisomers of tertiary amides bearing chiral imidazolidines or oxazolidin
(-)-Ephedrine as an auxiliary for the asymmetric synthesis of atropisomeric amides by dynamic resolution under thermodynamic control
Clayden, Jonathan,Lai, Lai Wah
, p. 3163 - 3166 (2007/10/03)
N,N-Dialkyl-2-formylbenzamides and N,N-dialkyl-2-formyl-1-naphthamides condense with (-)-ephedrine in refluxing toluene to give oxazolidines both as single diastereoisomers with respect to the new stereogenic centre and as single conformers with respect t
