722-04-3

Upstream product

• 109-55-7 1-amino-3-(dimethylamino)propane 
• 62-53-3 aniline 
• 4314-19-6 bis(1H-benzo[d][1,2,3]triazol-1-yl)methanethione 
• 103-72-0 phenyl isothiocyanate 
• 1738-25-6 3-dimethylaminopropiononitrile 

Downstream Products

• 57723-15-6 3-(3-dimethylamino-propylimino)-4-phenyl-3,4-dihydro-1H-benzo[e][1,3]thiazepin-5-one 
• 304443-97-8 N-{4-(4-bromophenyl)-3-[3-(dimethylamino)propyl]thiazol-2(3H)-ylidene}aniline 
• 1147841-10-8 3-(3-dimethylamino-propyl)-2-phenylimino-thiazolidin-4-one 
• 771476-32-5 2-(N-phenyl-aminooxy)-hexanal 
• 608130-30-9 (R)-3-methyl-2-(N-phenyl-aminooxy)-butan-1-ol 
• 608130-29-6 (R)-2-(N-phenyl-aminooxy)-hexan-1-ol 
• 771476-39-2 (2R)-3-methyl-2-(N-anilinyloxy)butanal 

Relevant academic research and scientific papers

Onium salt organic catalyst, and preparation method and application thereof

The invention discloses an onium salt organic catalyst. The catalyst has a structure as shown in a formula (I). In the formula (I), L is a urea or thiourea group; M is an onium salt structure with charges; y represents the number of urea or thiourea groups and can be any integer between 1 and 100000; and z represents the number of onium salt groups and can be any integer between 1 and 100000. The invention also discloses a preparation method of the onium salt organic catalyst. The preparation method comprises the following steps: mixing and stirring any reaction raw material W1 and any reaction raw material W2 in a solution, stirring at room temperature for 1-500 hours, and removing impurities and an organic solvent to obtain the onium salt organic catalyst. The invention also discloses an application of the onium salt organic catalyst in preparation of organic micromolecular and macromolecular polymers. The onium salt organic catalyst provided by the invention has the advantages of being easy to weigh, high in catalytic activity, controllable in reaction and the like; and the preparation method provided by the invention is simple and high in yield.

Insights into Thiourea-Based Bifunctional Catalysts for Efficient Conversion of CO2to Cyclic Carbonates

The bifunctional thiourea catalyst system with both electrophilic and nucleophilic centers has been certified to be effective for fixing CO2 under mild reaction conditions; however, many questions remain, especially concerning the relationship between str

A model for a solvent-free synthetic organic research laboratory: Click-mechanosynthesis and structural characterization of thioureas without bulk solvents

The mechanochemical click coupling of isothiocyanates and amines has been used as a model reaction to demonstrate that the concept of a solvent-free research laboratory, which eliminates the use of bulk solvents for either chemical synthesis or structural characterization, is applicable to the synthesis of small organic molecules. Whereas the click coupling is achieved in high yields by simple manual grinding of reactants, the use of an electrical, digitally controllable laboratory mill provides a rapid, quantitative and general route to symmetrical and non-symmetrical aromatic or aromatic-aliphatic thioureas. The enhanced efficiency of electrical ball milling techniques, neat grinding or liquid-assisted grinding, over manual mortar-and-pestle synthesis is demonstrated in the synthesis of 49 different thiourea derivatives. Comparison of powder X-ray diffraction data of mechanochemical products with structural information found in the Cambridge Structural Database (CSD), or obtained herein through single crystal X-ray diffraction, indicates that the mechanochemically obtained thiourea derivatives are pure in a chemical sense, but can also demonstrate purity in a supramolecular sense, i.e. in all structurally explored cases the product consisted of a single polymorph. As an extension of our previous work on solvent-free synthesis of coordination polymers, it is now demonstrated that such polymorphic and chemical purity of selected thiourea derivatives, the latter being evidenced through quantitative reaction yields, can enable the direct solvent-free structural characterization of mechanochemical products through powder X-ray diffraction aided by solid-state NMR spectroscopy.

Continuous proline catalysis via leaching of solid proline

Herein, we demonstrate that a homogeneous catalyst can be prepared continuously via reaction with a packed-bed of a catalyst precursor. Specifically, we perform continuous proline catalyzed α-aminoxylations using a packed-bed of L-proline. The system relies on a multistep sequence in which an aldehyde and thiourea additive are passed through a column of solid proline, presumably forming a soluble oxazolidinone intermediate. This transports a catalytic amount of proline from the packed-bed into the reactor coil for subsequent combination with a solution of nitrosobenzene, affording the desired optically active α-aminooxy alcohol after reduction. To our knowledge, this is the first example in which a homogeneous catalyst is produced continuously using a packedbed. We predict that the method will not only be useful for other L-proline catalyzed reactions, but we also foresee that it could be used to produce other catalytic species in flow.

Discovering potent inhibitors against the β-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of helicobacter pylori: Structure-based design, synthesis, bioassay, and crystal structure determination

The discovery of HpFabZ inhibitors is now of special interest in the treatment of various gastric diseases. In this work, three series of derivatives (compounds 3, 4, and 5) were designed, synthesized, and their biological activities were investigated as potential HpFabZ inhibitors in a two phased manner. First, we designed and synthesized two series of derivatives (3a-r and 4a-u) and evaluated the enzyme-based assay against HpFabZ. Five compounds (3i-k, 3m, and 3q) showed potential inhibitory activity, with IC50 values less than 2 μM. Second, a focused combinatorial library containing 280 molecules was designed employing the LD1.0 program. Twelve compounds (5a-l) were selected and synthesized. The activity of the most potent compound 5h (IC 50) 0.86 μM) was 46 times higher than that of the hit 1. The high hit rate and the potency of the new HpFabZ inhibitors demonstrated the efficiency of the strategy for the focused library design and virtual screening.

1-(Alkyl/Arylthiocarbamoyl)benzotriazoles as Stable Isothiocyanate Equivalents: Synthesis of Di- and Trisubstituted Thioureas

1-(Alkyl/arylthiocarbamoyl)benzotriazoles 4a-i were synthesized in yields of 91-99% from bis(benzotriazolyl)methanethione (3). Reagents 4a-g were then used as isothiocyanate equivalents for the efficient synthesis of 10 secondary and 14 tertiary thioureas

Method and composition for rejuvinating cells, tissues organs, hair and nails

In one embodiment, the present invention relates to compounds and compositions including pharmaceutical compositions containing the compounds and associated methods that uncouple sugar-mediated coupling of proteins, lipids, nucleic acids, and other biomat