72203-94-2

Basic information

• Product Name: N-[(S)-2-methoxymethylpyrrolidin-1-yl]propan-1-imine
• Synonyms: N-[(S)-2-methoxymethylpyrrolidin-1-yl]propan-1-imine
• CAS NO: 72203-94-2
• Molecular Weight: 170.255
• Mol File: 72203-94-2.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: N-[(S)-2-methoxymethylpyrrolidin-1-yl]propan-1-imine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(S)-2-methoxymethylpyrrolidin-1-yl]propan-1-imine(72203-94-2)
• EPA Substance Registry System: N-[(S)-2-methoxymethylpyrrolidin-1-yl]propan-1-imine(72203-94-2)

Safety Data

• Hazardous Substances Data: 72203-94-2(Hazardous Substances Data)

Upstream product

• 59983-39-0 (S)-1-amino-2-(methoxymethyl)pyrrolidine 
• 123-38-6 propionaldehyde 

Downstream Products

• 326591-12-2 (R)-(-)-2-methylpentyl p-nitrophenylsulfonate 
• 105-30-6 (S)-2-methyl-1-pentanol 
• 105-30-6 (R)-2-methylpentan-1-ol 
• 217460-28-1 (S)-(+)-2-methylpentyl p-nitrophenylsulfonate 
• 146968-02-7 <5(2E,4S,6S),7S>-2,7-Anhydro-8,9,10,12,13-pentadeoxy-10-methylene-3,4-bis-C-<(phenylmethoxy)carbonyl>-12-(phenylmethyl)-5-(4,6-dimethyl-2-octenoate)-L-erythro-L-glycero-D-altro-7-trideculo-7,4-furanosonic acid phenylmethyl ester 
• 192054-80-1 ((S)-2-Methoxymethyl-pyrrolidin-1-yl)-((1S,2R)-2-methyl-1,3-diphenyl-propyl)-amine 
• 192054-77-6 ((S)-2-Methoxymethyl-pyrrolidin-1-yl)-[(R)-1-((R)-1-methyl-2-phenyl-ethyl)-pentyl]-amine 
• 117555-29-0 (S)-2-Methyl-1-octanol tosylate 
• 7786-29-0 (S)-α-methyloctanal 
• 825601-16-9 (1R,1'R,2S)-(-)-[1-(2'-benzyloxy-1'-methylethyl)pentyl][2-(methoxymethyl)pyrrolidin-1-yl]amine 

Relevant articles and documents

COMPOUNDS FOR INHIBITING WIP1, PRODRUGS AND COMPOSITIONS THEREOF, AND RELATED METHODS

The invention provides compounds useful in inhibiting the activity of a Wip1 protein in a cell as well as prodrugs thereof, related methods of use and compositions which include the aforesaid compounds and prodrugs thereof. The compounds comprise a ring structure having at least five functional groups bonded thereto, wherein each functional group is bonded to a different ring atom, and wherein the at least five functional groups comprise: (a) first (R1) and second (R3) moieties each comprising a phosphate group wherein these first and second moieties are separated by at least one ring atom; (b) first (R2) and second (R4) hydrophobic groups, wherein the first and second hydrophobic groups are separated by at least one ring atom, and wherein the first hydrophobic group is bonded to a ring atom located between the ring atoms to which the first (R1) and second (R2) moieties are bonded; and an amide or carboxylic acid (R5).

Asymmetric synthesis of β-substituted γ-lactams employing the samp-/ramp-hydrazone methodology. Application to the synthesis of (R-(-)-baclofen

A short and efficient asymmetric synthesis of β-substituted γ-lactams is described. Key steps are the α-alkylation of aldehyde SAMP-hydrazones with alkyl bromoacetates, their MMPP mediated conversion to the corresponding nitriles and a reductive cyclization with Raney Ni or Ni boride to the title pyrrolidin-2-ones. The β-substituted γ-lactams are obtained in three steps, good overall yields (27-78%) and excellent enantiomeric excesses (ee=93-99%). The applicability of this procedure for the asymmetric synthesis of GABAs (γ-aminobutyric acids) is demonstrated for (R-(-)-baclofen hydrochloride, which is obtained in 4 steps 55% yield and 94% ee.

Asymmetric synthesis of all stereoisomers of 7,11-dimethylheptadecane and 7-methylheptadecane, the female pheromone components of the spring hemlock looper and the pitch pine looper

The asymmetric synthesis of the stereoisomers of 7,11-dimethylheptadecane (1) and 7-methylheptadecane (2) via α-alkylation employing the SAMP/RAMP hydrazone method with high asymmetric induction and good overall yields is described. A mixture of (7S,11R)-1 and (S)-2 is the female-produced sex pheromone of the spring hemlock looper moth (Lambdina athasaria) and the pitch pine looper moth (Lambdina pellucidaria). They are both forest pests in northeastern North America.