72204-99-0

Usage

Uses

Used in Pharmaceutical Industry:
VitaMin D2 Tosylate is used as a precursor for the preparation of Vitamin D analogues. These analogues are essential in the development of medications that target various health conditions, including bone disorders and certain cancers.
The specific application of VitaMin D2 Tosylate in the pharmaceutical industry is to serve as a starting material for the synthesis of Vitamin D analogues. These analogues have a wide range of therapeutic applications, making VitaMin D2 Tosylate a valuable compound in the development of new medications.

Upstream product

• 50-14-6 Calciferol 
• 98-59-9 p-toluenesulfonyl chloride 
• 50-14-6 Vitamin D₂ 

Downstream Products

• 87649-67-0 doxercalciferol 
• 74007-20-8 1α-hydroxy-5,6-trans-vitamin D₂ 
• 136463-23-5 Toluene-4-sulfonic acid (S)-3-[(1R,3aS,7aR)-7a-methyl-1-((S)-1-methyl-2-oxo-ethyl)-octahydro-inden-(4E)-ylidenemethyl]-2,2-dioxo-2,3,4,5,6,7-hexahydro-1H-2λ⁶-benzo[c]thiophen-5-yl ester 
• 97903-28-1 (6RS)-6-methoxy-23,24-bisnor-9,10-seco-3,5-cyclochola-9,10⁽¹⁹⁾-dien-22-yl p-toluenesulfonate 
• 136463-24-6 22-hydroxy-6,19-episulfono-23,24-bisnor-9,10-secochola-5(10),7-dien-3β-yl p-toluenesulfonate 
• 136463-25-7 (6RS)-<6-methoxy-23,24-bisnor-9,10-seco-3,5-cyclochola-7,10(19)-dien-22-yl> phenyl sulfone 
• 73809-46-8 5,6-trans-1α-Hydroxyvitamin D₂ 3-acetate 
• 73809-45-7 5,6-cis-1α-Hydroxyvitamin D₂ 3-acetate 
• 74007-20-8 5,6-trans-1α-Hydroxyvitamin D₂ 
• 54573-75-0 1α-Hydroxyvitamin D₂ 

Relevant academic research and scientific papers

Degree-of-freedom alcohol and preparation method thereof

The invention provides alcidol and a preparation method thereof, and the preparation method comprises the following steps: D. 2 The initial material is subjected to a sulfonylation reaction in sequence. The methoxy - is reacted with a bridging

Based on nitrogen heterocyclic modified vitamin D2 derivatives, synthesis and use

The invention discloses a vitamin D2 derivative modified by N-heterocycle, as well as synthesis and application of the vitamin D2 derivative. The vitamin D2 derivative is synthesized through the following steps: taking vitamin D2 as a raw material, and co

STABILIZED DOXERCALCIFEROL AND PROCESS FOR MANUFACTURING THE SAME

1 a-hydroxy vitamin D2 (doxercalciferol) of exceptionally high purity and stability is prepared by a process involving chromatographically purifying 1 α-hydroxyvitamin D2 monoacetate, chemically removing the acetate protectant group

METHODS FOR PRODUCING PARICALCITOL

The present invention is directed to novel processes for the preparation of paricalcitol to novel intermediates used in these processes, and to processes for preparation of the novel intermediates.

Process for preparation of paricalcitol and intermediates thereof

The invention relates to a novel process for the preparation of Paricalcitol and intermediates thereof.

PROCESS FOR PREPARATION OF PARICALCITOL INTERMEDIATES

The present invention relates to a compound and a novel process for the preparation of Paricalcitol intermediates.

Convenient synthesis of 1α,25-dihydroxyvitamin D3 from vitamin D2

(1S,6R)-1-Acetoxy-6-(1,3-benzodithiol-2-yloxy)-3,5-cyclovitamin D2 (7) was synthesized from vitamin D2 by five steps. The new compound 7 was ozonized regioselectively and subsequently reduced, leading to (7E)-(1S,3S,5R,6R)-1-acetoxy-6-(1,3-benzodithiol-2-yloxy)-3,5-cyclo-9, 10-seco-23,24-dinor-7,10(19)-choladien-22-ol (11). The alcohol 11 obtained as a key intermediate was tosylated, iodinated, and coupled with 2-methyl-4-phenylsulfonyl-2-(tetrahydropyranyloxy)butane to give (1S,6R)-1-hydroxy-6-(1,3-benzodithiol-2-yloxy)-23-phenylsulfonyl-25-te trahydropyranyloxy-3,5-cyclovitamin D3 (16). By desulfonylation and hydrolysis of the compound 16 1α,25-dihydroxyvitamin D3 was obtained selectively.

SYNTHESIS OF (24R)-24,25-DIHYDROXYVITAMIN D3

Two versions of the stereoselective synthesis of (24R)-24,25-dihydroxyvitamin D3 were realized.Vitamin D2 and ergosterol were used as starting materials.Methods are proposed for the production of the following key compounds: 6-Methoxy-23,24-bisnor-9,10-seco-3,5-cyclochola-7,10(19)-dien-22-yl phenyl sulfone; 3β-hydroxy-23,24-bisnorchola-5,7-dien-22-yl phenyl sulfone; (2R)-3-methylbutane-1,2,3-triol 1-p-toluenesulfonate.

Direct C(1) Hydroxylation of Vitamin D3 and Related Compounds

A direct synthesis of C(1) hydroxylated vitamin D analogues from the corresponding vitamin D precursors has been developed.Allylic oxidation of 3,5-cyclovitamin D derivatives, readily obtained from the buffered solvolysis of vitamin D tosylates, with selenium dioxide yields 1α-hydroxylated 3,5-cyclovitamin D compounds which are smoothly converted to the desired 1α-hydroxyvitamin D derivatives by acid-catalyzed cycloreversion.Application of this scheme to vitamin D3 (1a), 25-hydroxyvitamin D3 (1b), and vitamin D2 (1c) affords the 1α-hydroxy products in ca.20 percent overall yield.