72215-98-6

Basic information

• Product Name: C₂₃⁽¹⁴⁾CH₂₆F₅NO₃
• CAS NO: 72215-98-6
• Molecular Weight: 473.456
• Mol File: 72215-98-6.mol

Chemical Properties

• CAS DataBase Reference: C₂₃⁽¹⁴⁾CH₂₆F₅NO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃⁽¹⁴⁾CH₂₆F₅NO₃(72215-98-6)
• EPA Substance Registry System: C₂₃⁽¹⁴⁾CH₂₆F₅NO₃(72215-98-6)

Safety Data

• Hazardous Substances Data: 72215-98-6(Hazardous Substances Data)

Relevant articles and documents

Labelling of neuroleptic butyrophenones. II. Synthesis of 2' amino 4' fluoro 4 [4 hydroxy 4 (3 trifluoromethylphenyl)piperidino]butyrophenone (carbonyl 14C)

2'-Amino-4'-fluoro-4-[4-hydroxy-4-(3-trifluoromethylphenyl)-piperidino]butyrophenone (1), a novel neuroleptic agent, was labelled with carbon-14 at the carbonyl position for use in metabolic studies. The synthesis was achieved according to the reaction scheme shown. Cyclopropyl 2,4-difluorophenyl ketone-(carbonyl-14C) (2a) was prepared from cyclopropane-carboxylic-14C acid by the Friedel-Crafts reaction with m-difluorobenzene. Ring-opening of 2a with hydrogen chloride gave 4-chloro-2',4'-difluorobutyrophenone-1-14C (3a). After ketalization of 3a, the resulted ketal was condensed with the piperidine and subsequently hydrolyzed with hydrochloric acid to give 6. Benzylamination of 6 with benzylamine, followed by debenzylation by catalytic hydrogenolysis gave ID-4708-(carbonyl-14C) (1). The overall radiochemical yield of 1 from barium carbonate-14C was 13%.