72216-08-1

Usage

InChI:InChI=1/C11H10F3N/c12-11(13,14)9-5-3-8(4-6-9)10-2-1-7-15-10/h3-6H,1-2,7H2

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 88-12-0 1-ethenyl-2-pyrrolidinone 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 29480-10-2 1-(4-(trifluoromethyl)phenyl)cyclobutan-1-ol 

Downstream Products

• 126328-76-5 C₁₅H₁₂⁽²⁾H₄F₃N 
• 126328-48-1 C₁₅H₁₂⁽²⁾H₄F₃N 
• 126328-46-9 2-Methylene-7a-(4-trifluoromethyl-phenyl)-hexahydro-pyrrolizine 
• 1217816-57-3 2-[4-(trifluoromethyl)phenyl]pyrrolidine 

Relevant academic research and scientific papers

Synthesis of 1-Pyrroline by Denitrogenative Ring Expansion of Cyclobutyl Azides under Thermal Conditions

We herein report an efficient and systematic synthesis of 1-pyrrolines from cyclobutyl azides under thermal and neutral conditions. The reaction proceeded without any additional reagents, and nitrogen was generated as the sole by-product. Furthermore, the generated 1-pyrrolines could be continuously transformed into pyrroles, N-Boc-amines, and oxaziridines in an one-pot manner. (Figure presented.).

Hammett correlation of nornicotine analogues in the aqueous aldol reaction: Implications for green organocatalysis

(Chemical Equation Presented) A series of meta- and para-substituted 2-arylpyrrolidines were synthesized and examined for their ability to catalyze an aqueous aldol reaction under buffered conditions. Kinetic analysis of arylpyrrolidine-catalyzed reactions displayed a linear Hammett correlation with ρ = 1.14 (R2 = 0.996), indicating that the reaction is accelerated by electron-withdrawing aryl rings. These results show promise for the development of a synthetically viable aqueous organocatalyst.