72216-31-0Relevant academic research and scientific papers
Ligand-accelerated ortho -C-H alkylation of arylcarboxylic acids using alkyl boron reagents
Thuy-Boun, Peter S.,Villa, Giorgio,Dang, Devin,Richardson, Paul,Su, Shun,Yu, Jin-Quan
supporting information, p. 17508 - 17513 (2014/01/06)
A protocol for the Pd(II)-catalyzed ortho-C-H alkylation of phenylacetic and benzoic acids using alkylboron reagents is disclosed. Monoprotected amino acid ligands (MPAA) were found to significantly promote reactivity. Both potassium alkyltrifluoroborates and alkylboronic acids were compatible coupling partners. The possibility of a radical alkyl transfer to Pd(II) was also investigated.
A new method for hydrolyzing 2-aryl-4,4-dimethyl-2-oxazolines to aryl carboxylic acids
Phillion,Pratt
, p. 13 - 22 (2007/10/02)
A method of hydrolyzing 2-aryl-4,4-dimethyl-2-oxazolines with trifluoromethanesulfonic anhydride is described which works well even for highly hindered systems where alternate methods fail.
