72219-10-4

Upstream product

• 151-50-8 potassium cyanide 
• 100-46-9 benzylamine 
• 29897-82-3 N-benzylpyrrolidine 
• 143-33-9 sodium cyanide 

Downstream Products

• 115995-98-7 1-benzyl-2,5-dicyano-2-hexylpyrrolidine 
• 111138-55-7 (2R,5R)-dimethyl 1-benzylpyrrolidine-2,5-dicarboxylate 
• 118396-01-3 (-)-(2S,5S)-N-benzyl-trans-2,5-bis(methoxycarbonyl)pyrrolidine 
• 52321-07-0 (2R,5R)-1-Benzyl-pyrrolidine-2,5-dicarboxylic acid 
• 115996-00-4 trans 1-benzyl-2,5-dicyano-2-hexyl-5-methylpyrrolidine 
• 115996-00-4 cis 1-benzyl-2,5-dicyano-2-hexyl-5-methylpyrrolidine 
• 115996-01-5 cis 2-hexyl-1-benzyl-2,5-dicyano-5-ethylpyrrolidine 

Relevant academic research and scientific papers

EFFICIENT SYNTHESIS OF 1-SUBSTITUTED 2,5-DICYANOPYRROLIDINES BY THE STRECKER REACTION USING SUCCINALDEHYDE AND PRIMARY AMINES, AND THEIR STEREOCHEMISTRY

An efficient sequence proposed here for new synthesis of 1-substituted 2,5-dicyanopyrrolidines involves the simple Strecker reaction using succinaldehyde bis-sodium bisulfite and primary amines.Furthermore, their stereochemistry is also discussed.

Trapping of Metabolically Generated Electrophilic Species with Cyanide Ion: Metabolism of 1-Benzylpyrrolidine

Incubations of 1-benzylpyrrolidine (4) and specifically deuterium-labeled analogues of 4 with rabbit liver microsomal preparations in the presence of cyanide ion have led to the characterization of 1-benzyl-2-cyanopyrrolidine (13), cis- and trans-1-benzyl