72233-91-1

Basic information

• Product Name: 1-METHYL-1-(M-TOLYL)HYDRAZINE
• Synonyms: 1-METHYL-1-(3-METHYLPHENYL)HYDRAZINE;1-METHYL-1-(M-TOLYL)HYDRAZINE;1-Methyl-1-(m-tolyl)hydrazine
• CAS NO: 72233-91-1
• Molecular Formula: C₈H₁₂N₂
• Molecular Weight: 136.19
• Mol File: 72233-91-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 245.1°C at 760 mmHg
• Flash Point: 121°C
• Appearance: /
• Density: 1.02
• Vapor Pressure: 0.0292mmHg at 25°C
• Refractive Index: 1.5700 to 1.5740
• PKA: 5.50±0.12(Predicted)
• CAS DataBase Reference: 1-METHYL-1-(M-TOLYL)HYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-1-(M-TOLYL)HYDRAZINE(72233-91-1)
• EPA Substance Registry System: 1-METHYL-1-(M-TOLYL)HYDRAZINE(72233-91-1)

Safety Data

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 72233-91-1(Hazardous Substances Data)

Usage

General Description

1-Methyl-1-(m-tolyl)hydrazine is a chemical compound with the formula C9H14N2. It is a colorless to pale yellow liquid with a fishy odor. 1-METHYL-1-(M-TOLYL)HYDRAZINE is primarily used as an intermediate in the production of pharmaceuticals, pesticides, and pigments. It is also used as a propellant in rocket and missile systems. 1-Methyl-1-(m-tolyl)hydrazine is a highly flammable and toxic compound, and proper safety precautions should be taken when handling and storing it. Exposure to this chemical can cause irritation to the eyes, skin, and respiratory system, as well as more severe health effects if ingested or inhaled in high concentrations.

InChI:InChI=1/C8H12N2/c1-7-4-3-5-8(6-7)10(2)9/h3-6H,9H2,1-2H3

Upstream product

• 17485-25-5 3-methyl-N-nitroso-N-methylaniline 
• 696-44-6 N-methyl-m-toluidine 

Downstream Products

• 81817-14-3 7-methyl-3-phenylbenzo[e][1,2,4]triazine 
• 1610871-11-8 1,6-dimethyl-2,3-diphenyl-1H-indole 
• 78386-74-0 1,3,6-trimethyl-2-phenyl-1H-indole 
• 1416897-81-8 (E)-methyl 3-(4-methyl-2-(methylamino)phenyl)acrylate 

Relevant articles and documents

Cobalt-Catalyzed, Directed Intermolecular C-H Bond Functionalization for Multiheteroatom Heterocycle Synthesis: The Case of Benzotriazine

Transition-metal-catalyzed, directed intermolecular C-H bond functionalization is synthetically useful but heavily underexplored in multiheteroatom heterocycle synthesis. Herein we report a cobalt catalytic method for the formation of a three-nitrogen-bearing benzotriazine scaffold via the coupling of arylhydrazine and oxadiazolone. This synthetic protocol features a low-cost base metal catalyst, a maximum number of heteroatoms built into a heterocycle, a distinct synthetic logic for benzotriazines, a superior step economy, and a broad substrate scope.

A Versatile, Traceless C-H Activation-Based Approach for the Synthesis of Heterocycles

A versatile, traceless C-H activation-based approach for the synthesis of diversified heterocycles is reported. Rh(III)-catalyzed, N-amino-directed C-H alkenylation generates either olefination products or indoles (in situ annulation) in an atom- and step-economic manner at room temperature. The remarkable reactivity endowed by this directing group enables scale-up of the reaction to a 10 g scale at a very low catalyst loading (0.01 mol %/0.1 mol %). Ex situ annulation of olefination product provides entry into an array of heterocycles.