72233-91-1

Usage

Uses

Used in Pharmaceutical Production:
1-METHYL-1-(M-TOLYL)HYDRAZINE is used as a key intermediate in the synthesis of pharmaceuticals, contributing to the development of various medications due to its reactive chemical properties.
Used in Pesticide Manufacturing:
1-METHYL-1-(M-TOLYL)HYDRAZINE is also employed as an intermediate in the production of pesticides, playing a crucial role in the creation of effective and targeted pest control agents.
Used in Pigment Industry:
1-METHYL-1-(M-TOLYL)HYDRAZINE is utilized in the synthesis of pigments, contributing to the coloration and stability of various products in different industries.
Used in Aerospace Propellants:
In the aerospace industry, 1-METHYL-1-(M-TOLYL)HYDRAZINE is used as a propellant in rocket and missile systems, leveraging its flammability to enable propulsion.

InChI:InChI=1/C8H12N2/c1-7-4-3-5-8(6-7)10(2)9/h3-6H,9H2,1-2H3

Upstream product

• 696-44-6 N-methyl-m-toluidine 
• 17485-25-5 3-methyl-N-nitroso-N-methylaniline 

Downstream Products

• 1610871-11-8 1,6-dimethyl-2,3-diphenyl-1H-indole 
• 81817-14-3 7-methyl-3-phenylbenzo[e][1,2,4]triazine 
• 78386-74-0 1,3,6-trimethyl-2-phenyl-1H-indole 
• 1416897-81-8 (E)-methyl 3-(4-methyl-2-(methylamino)phenyl)acrylate 

Relevant academic research and scientific papers

Cobalt-Catalyzed, Directed Intermolecular C-H Bond Functionalization for Multiheteroatom Heterocycle Synthesis: The Case of Benzotriazine

Transition-metal-catalyzed, directed intermolecular C-H bond functionalization is synthetically useful but heavily underexplored in multiheteroatom heterocycle synthesis. Herein we report a cobalt catalytic method for the formation of a three-nitrogen-bearing benzotriazine scaffold via the coupling of arylhydrazine and oxadiazolone. This synthetic protocol features a low-cost base metal catalyst, a maximum number of heteroatoms built into a heterocycle, a distinct synthetic logic for benzotriazines, a superior step economy, and a broad substrate scope.

Rh(iii)-catalyzed, hydrazine-directed C-H functionalization with 1-alkynylcyclobutanols: A new strategy for 1: H -indazoles

Rh(iii)-catalyzed coupling of phenylhydrazines with 1-alkynylcyclobutanols was realized through a hydrazine-directed C-H functionalization pathway. This [4+1] annulation, based on the cleavage of a Csp-Csp triple bond in alkynylcyclobutanol, provides a new pathway to prepare diverse 1H-indazoles under mild reaction conditions. This journal is

A Versatile, Traceless C-H Activation-Based Approach for the Synthesis of Heterocycles

A versatile, traceless C-H activation-based approach for the synthesis of diversified heterocycles is reported. Rh(III)-catalyzed, N-amino-directed C-H alkenylation generates either olefination products or indoles (in situ annulation) in an atom- and step-economic manner at room temperature. The remarkable reactivity endowed by this directing group enables scale-up of the reaction to a 10 g scale at a very low catalyst loading (0.01 mol %/0.1 mol %). Ex situ annulation of olefination product provides entry into an array of heterocycles.

Ruthenium(II)-Catalyzed Traceless C?H Functionalization Using an N?N Bond as an Internal Oxidant

A previously elusive RuII-catalyzed N?N bond-based traceless C?H functionalization strategy is reported. An N-amino (i.e., hydrazine) group is used for the directed C?H functionalization with either an alkyne or an alkene, affording an indole derivative or olefination product. The synthesis features a broad substrate scope, superior atom and step economy, as well as mild reaction conditions.