72234-52-7

Upstream product

• 1087-09-8 1,4-diphenyl-but-2-yne-1,4-dione 
• 17572-77-9 (3E)-1,4-diphenylbut-3-en-1-one 

Downstream Products

• 72624-43-2 4,7-diphenyl-6-hydroxymethyl-1,2,5-thiadiazolo<3,4-c>pyridine 
• 72624-40-9 4,6,7-triphenyl-1,2,5-thiadiazolo<3,4-c>pyridine 
• 72624-44-3 ethyl 4,7-diphenyl-1,2,5-thiadiazolo<3,4-c>pyridine-6-carboxylate 
• 24793-25-7 4,6-diphenylthieno<3,4-c><1,2,5>thiadiazole 
• 87255-86-5 6-benzyl-4,7-diphenyl-1,2,5-thiadiazolo<3,4-c>pyridine 
• 87255-85-4 N-<3-(4-benzoyl)-1,2,5-thiadiazolyl>benzylidene-β-phenylethylamine 
• 85731-26-6 m-bis(4,7-diphenyl-1,2,5-thiadiazolo<3,4-c>pyridino)benzene 
• 85731-27-7 p-bis(4,7-diphenyl-1,2,5-thiadiazolo<3,4-c>pyridino)benzene 
• 87255-89-8 ethyl N-<3-(4-benzoyl)-1,2,5-thiadiazolyl>benzylidene-β-amino-β-phenylpropionate 
• 5398-63-0 2,5-diphenylpyrazine 
• 76593-54-9 (4,7-Diphenyl-[1,2,5]thiadiazolo[3,4-c]pyridin-6-yl)-phenyl-methanone 
• 76593-50-5 4,7-Diphenyl-[1,2,5]thiadiazolo[3,4-c]pyridine-6-carboxylic acid methyl ester 
• 85731-29-9 4,7-diphenyl-6-vinyl-1,2,5-thiadiazolo<3,4-c>pyridine 
• 76593-53-8 6-cyano-4,7-diphenyl-1,2,5-thiadiazolo<3,4-c>pyridine 

Relevant academic research and scientific papers

Reaction of trithiazyl trichloride with active methylene compounds

Activated allylic compounds react with trithiazyl trichloride, (NSCl)3, to give 1,2,5-thiadiazoles 1 and isothiazoles 2. An allylic 2-substituent normally prevents formation of an aromatic 1,2,5-thiadiazole, and isothiazole formation becomes the major pathway. Simple allylic compounds are not very reactive towards (NSCl)3 but a terminal electron withdrawing group (CO2Et) enhances the reactivity. With unsymmetrical allylic compounds, isothiazole formation is regiospecific placing the more electron withdrawing group adjacent to the ring sulfur. 1,3-Diketones give 3-acyl-1,2,5-thiadiazoles; unsymmetrical 1,3-diketones give these thiadiazoles regiospecifically, explicable by cyclisation of an intermediate onto the more reactive carbonyl group. 1,4-Diketones give 3,4-diacyl-1,2,5-thiadiazoles; thus 1,2-dibenzoyl-ethane,-echene and -ethyne all give 3,4-dibenzoylthiadiazole (40-44%). Many of these trithiazyl trichloride reactions provide attractive one-step routes to 1,2,5-thiadiazoles and isothiazoles.