72236-70-5Relevant academic research and scientific papers
Preparation method of sodium beta-glycerophosphate containing crystal water
-
Page/Page column 5-7, (2020/12/08)
The invention discloses a preparation method of sodium beta-glycerophosphate containing crystal water. The method comprises the following steps: A) taking epoxy chloropropane as an initial raw material, slowly dropwise adding the epoxy chloropropane into hydrochloric acid, reacting for 1-6 hours, adjusting the pH value to 3-4 by using a sodium hydroxide solution, carrying out vacuum distillation to remove moisture, distilling to 60 DEG C, adding a drying agent, stirring for 1 hour, and filtering to obtain 1, 3-dichloropropanol; B) adding the 1,3-dichloropropanol into an esterification reactionkettle, adding a phosphating agent, heating the temperature to 80-130 DEG C, controlling the temperature to esterify for 10-20 hours, after esterification is finished, adding water for dilution, dropwise adding the sodium hydroxide solution, adjusting the pH value to be 9-13, keeping the temperature at 40-80 DEG C, hydrolyzing for 3-5 hours, adding magnesium oxide or calcium oxide and stirring for 2 hours at 60-80 DEG C, adding activated carbon and stirring for 1 hour, the negative pressure distillation concentration being 70%-75%, adding ethyl alcohol, carrying out cooling and stirring and filtering to obtain the sodium beta-glycerophosphate. According to the invention, the generation of sodium alpha-glycerophosphate is avoided, and the sodium beta-glycerophosphate containing crystal water and not containing crystal water can be flexibly prepared.
