72237-98-0

Basic information

• Product Name: 1-chloro-9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole
• Synonyms: 1-chloro-9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole
• CAS NO: 72237-98-0
• Molecular Formula: C₁₈H₁₅ClN₂O
• Molecular Weight: 310.7775
• EINECS: 276-510-4
• Mol File: 72237-98-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 552.2°C at 760 mmHg
• Flash Point: 287.8°C
• Appearance: /
• Density: 1.34g/cm³
• Vapor Pressure: 1.12E-11mmHg at 25°C
• Refractive Index: 1.74
• CAS DataBase Reference: 1-chloro-9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole(72237-98-0)
• EPA Substance Registry System: 1-chloro-9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole(72237-98-0)

Safety Data

• Hazardous Substances Data: 72237-98-0(Hazardous Substances Data)

Usage

Class

Pyrido[4,3-b]carbazoles

Type

Synthetic compound

Biological and Pharmacological Activities

Potential applications in medicinal chemistry

Structure

Chlorine atom and methoxy group attached to the pyrido[4,3-b]carbazole ring

Substituents

Two methyl groups at specific positions (5 and 11)

Applications

Potential drug candidate or research tool for studying structure-activity relationships

Fields of Interest

Pharmacology and organic chemistry

Potential Uses

Studying the chemical properties and biological activities of the compound

Research Focus

Structure-activity relationships of related compounds and their potential applications in drug development

InChI:InChI=1/C18H15ClN2O/c1-9-12-6-7-20-18(19)16(12)10(2)15-13-8-11(22-3)4-5-14(13)21-17(9)15/h4-8,21H,1-3H3

Upstream product

• 148729-98-0 1,9-Dimethoxy-5,11-dimethyl-6H-pyrido<4,3-b>carbazole 

Downstream Products

• 1241893-93-5 9-methoxy-2,5,11-trimethyl-6H-pyrido[4,3-b]carbazol-1-one 
• 72238-02-9 Retelliptine 
• 83948-11-2 N-ethyl-N'-(9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazol-1-yl)-propane-1,3-diamine 
• 115464-66-9 Isobutyl-(9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazol-1-yl)-amine 
• 74861-72-6 N-(9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazol-1-yl)-propane-1,3-diamine 

Relevant articles and documents

Industrial synthesis in mass production. Ellipticine. II. The elaboration of a new approach to GH-pyrido[4,3:b]carbazoles and analogs. B. The recovery of tetracyclic structures

Total synthesis of modified ellipticines 1c and 1f is described from 2-chloronicotinic acid and respectively 5-methoxy-indole and 5-azaindole in 11 to 13 steps with overall yields of 11% and 18%. With respect to the numerous synthesis described in the literature, the originality of this approach resides above all in the formation of ring C in basic medium, such conditions being dictated by the presence of the pyridine A ring in the case of 1f. Both synthesis have been extrapolated to produce several kilograms of final product. The second part deals with the elaboration of tetracyclic structures from precursors.