72239-33-9

Basic information

• Product Name: 2-((m-Trifluoromethylbenzyl)amino)-2-thiazoline
• Synonyms: 2-((m-Trifluoromethylbenzyl)amino)-2-thiazoline
• CAS NO: 72239-33-9
• Molecular Formula: C₁₁H₁₁F₃N₂S
• Molecular Weight: 0
• Mol File: 72239-33-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 327.9°C at 760 mmHg
• Flash Point: 152.1°C
• Appearance: /
• Density: 1.36g/cm³
• Vapor Pressure: 0.000196mmHg at 25°C
• Refractive Index: 1.565
• CAS DataBase Reference: 2-((m-Trifluoromethylbenzyl)amino)-2-thiazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((m-Trifluoromethylbenzyl)amino)-2-thiazoline(72239-33-9)
• EPA Substance Registry System: 2-((m-Trifluoromethylbenzyl)amino)-2-thiazoline(72239-33-9)

Safety Data

• Hazardous Substances Data: 72239-33-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H11F3N2S/c12-11(13,14)9-3-1-2-8(6-9)7-16-10-15-4-5-17-10/h1-3,6H,4-5,7H2,(H,15,16)

Upstream product

• 72239-23-7 N-(4,5-dihydro-thiazol-2-yl)-3-trifluoromethyl-benzamide 
• 74788-77-5 (3-Trifluoromethyl-benzyl)-dithiocarbamic acid methyl ester 
• 61290-47-9 1-(2-Hydroxy-ethyl)-3-(3-trifluoromethyl-benzyl)-thiourea 
• 2251-65-2 3-(Trifluoromethyl)benzoyl chloride 
• 2740-83-2 3-(TRIFLUOROMETHYL)BENZYLAMINE 

Relevant articles and documents

Synthesis and Octopaminergic Agonist Activity of 2-(Substituted benzylamino)-2-thiazolines

2-(Substituted benzylamino)-2-thiazolines (SBAT) were synthesized by a hydrochloric acid-catalyzed cyclization of the corresponding thioureas, using a reaction of 2-methylthio-2-thiazoline with substituted benzylamines or by alkylating 2-amino-2-thiazoline. 2-(Alkylthio)-2-thiazolines were obtained by alkylating 2-mercaptothiazoline.Most of the SBAT compounds activated adenylate cyclase in homogenates of cockroach ventral nerve cords; the effect of introducing substituents at the phenyl of the SBAT compounds on octopaminergic agonist activity was not significant. 2--2-thiazolines and 2-(alkylthio)-2-thiazolines were not significant octopaminergic agonists.Washing removed nearly all of the activity of one of the SBAT compounds, suggesting that the SBAT compounds bound reversibly to the octopaminergic receptor.

2-Aminothiazoline derivatives. Relationships between structure and antiinflammatory activity

Pharmacological studies of 2-aminothiazoline amide and amine derivatives show these compounds to be actively anti-inflammatory. The structure determination by spectroscopic methods and X-ray diffraction indicates a relation between the structure and the activity of these compounds.