72242-26-3Relevant academic research and scientific papers
Palladium-catalysed and phosphine-promoted synthesis of diaryl ethers through self-coupling
Wang, Dawei,Xu, Zhaojun,Yu, Xiaoli,Li, Yongliang,Wan, Huida
, p. 691 - 693 (2016)
An efficient, palladium acetate-catalysed, tributylphosphine-promoted direct synthesis of symmetrical diaryl ethers through the self-coupling of aryl fluorides has been developed with K2CO3/ZrO2 as a base. This provides an alternative method to prepare aromatic polymers, important synthetic intermediates and natural products for use in the field of pharmaceuticals and industrial materials.
Iridium-catalyzed synthesis of diaryl ethers by means of chemoselective C-F bond activation and the formation of B-F bonds
Chen, Jianping,Zhao, Keyan,Ge, Bingyang,Xu, Chongying,Wang, Dawei,Ding, Yuqiang
supporting information, p. 468 - 473 (2015/02/05)
Transition-metal-catalyzed C-F activation, in comparison with C-H activation, is more difficult to achieve and therefore less fully understood, mainly because carbon-fluorine bonds are the strongest known single bonds to carbon and have been very difficult to cleave. Transition-metal complexes are often more effective at cleaving stronger bonds, such as C(sp2)-X versus C(sp2)-X. Here, the iridium-catalyzed C-F activation of fluorarenes was achieved through the use of bis(pinacolato)diboron with the formation of the B-F bond and self-coupling. This strategy provides a convenient method with which to convert fluoride aromatic compounds into symmetrical diaryl ether compounds. Moreover, the chemoselective products of the C-F bond cleavage were obtained at high yields with the C-Br and C-Cl bonds remaining.
