72247-61-1Relevant academic research and scientific papers
Chemical and Biochemical Modifications of Parthenin
Das, Biswanath,Venkataiah, B.,Kashinatham, A.
, p. 6585 - 6594 (1999)
Parthenin, a medicinally important natural sesquiterpenoid and a potent allelochemical underwent different regio- and stereoselective modifications to several interesting analogues by chemical and biochemical means. The compound was treated with various common reducing agents including NaBH4, NaBH4/I2, Na/EtOH, Mg/MeOH and Zn/HOAc as well as with different oxidizing agents including m-CPBA and dilute HCl under different reaction conditions. The retention of the α-methylene-γ-lactone moiety which plays a vital role for bioactivity of the compound was observed in some of the reaction products. The microwave irradiation of the compound afforded anhydroparthenin as the only product. Baker's yeast reduction of parthenin was investigated for the first time and yielded the naturally occurring dihydrocoronopilin. - Keywords: parthenin, sesquiterpenoid, α-methylene-γ-lactone, chemical modifications, baker's yeast reduction.
Modification of parthenin
Saxena, D B,Dureja, P,Kumar, B,Rani, Daizy,Kohli, R K
, p. 849 - 852 (2007/10/02)
Parthenin, the principal chemical constituent of Parthenium hysterophorus weed has been transformed chemically and photochemically with a view to study the structure-activity relationship for allelopathic effects.Chemical transformation gives three products replacing the exocyclic methylene double bond of the lactone ring by a pyrazoline nucleus, a cyclopropane ring and a propenyl group.Photochemical reaction leads to the formation of a hemiacetal and a lactone in place of the cyclopentenone moiety alongwiith dehydrated parthenin.Cyclopropyl analogue has been found to be most effective against Phaseolus aureus when compared to parthenin.
