722499-85-6

Upstream product

• 722499-78-7 2-(R)-tert-butoxycarbonylamino-N-[2-(4-hydroxyphenyl)ethyl]-3-phenylpropionamide 
• 18942-49-9 Boc-D-Phe-OH 
• 51-67-2 tyrosamine 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 722499-70-9 2-(R)-amino-N-[2-(4-hydroxyphenyl)ethyl]-3-phenylpropionamide 

Downstream Products

• 722499-87-8 (2S,5R)-5-benzyl-3-(4-hydroxyphenethyl)-1-(2,2,2-trifluoroacetyl)-2-(3,4,5-trimethoxyphenyl)imidazolidin-4-one 

Relevant academic research and scientific papers

Total synthesis of (-)-galanthamine by remote asymmetric induction

A pivotal intramolecular Michael addition to form a fused 5,7,5 ring system and the skeleton of (-)-galanthamine (1) was completely controlled by a remote chiral imidazolidinone auxiliary derived from D-phenylalanine (see scheme). This total synthesis of the allylic alcohol 1 avoids the corresponding enone narwedine, a highly allergenic intermediate in previous syntheses of 1.