722499-86-7

Basic information

• Product Name: 4-Imidazolidinone, 3-[2-(4-hydroxyphenyl)ethyl]-2-[4-methoxy-3,5-bis(phenylmethoxy)phenyl ]-5-(1-methylethyl)-, (2S,5R)-
• CAS NO: 722499-86-7
• Molecular Formula: C35H38N2O5
• Molecular Weight: 566.697
• Mol File: 722499-86-7.mol

Chemical Properties

• CAS DataBase Reference: 4-Imidazolidinone, 3-[2-(4-hydroxyphenyl)ethyl]-2-[4-methoxy-3,5-bis(phenylmethoxy)phenyl ]-5-(1-methylethyl)-, (2S,5R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Imidazolidinone, 3-[2-(4-hydroxyphenyl)ethyl]-2-[4-methoxy-3,5-bis(phenylmethoxy)phenyl ]-5-(1-methylethyl)-, (2S,5R)-(722499-86-7)
• EPA Substance Registry System: 4-Imidazolidinone, 3-[2-(4-hydroxyphenyl)ethyl]-2-[4-methoxy-3,5-bis(phenylmethoxy)phenyl ]-5-(1-methylethyl)-, (2S,5R)-(722499-86-7)

Safety Data

• Hazardous Substances Data: 722499-86-7(Hazardous Substances Data)

Upstream product

• 722499-79-8 2-(R)-tert-butoxycarbonylamino-N-[2-(4-hydroxyphenyl)ethyl]-3-methylbutyramide 
• 51-67-2 tyrosamine 
• 13326-72-2 3,5-bis(benzyloxy)-4-methoxybenzaldehyde 
• 722499-84-5 2-(R)-amino-N-[2-(4-hydroxyphenyl)ethyl]-3-methylbutyramide 
• 22838-58-0 Boc-D-Val-OH 

Downstream Products

• 722499-88-9 (2S,5R)-2-(3,5-dibenzyloxy-4-methoxyphenyl)-3-(4-hydroxyphenethyl)-5-isopropyl-1-(2,2,2-trifluoroacetyl)imidazolidin-4-one 

Relevant articles and documents

Total synthesis of (-)-galanthamine by remote asymmetric induction

A pivotal intramolecular Michael addition to form a fused 5,7,5 ring system and the skeleton of (-)-galanthamine (1) was completely controlled by a remote chiral imidazolidinone auxiliary derived from D-phenylalanine (see scheme). This total synthesis of the allylic alcohol 1 avoids the corresponding enone narwedine, a highly allergenic intermediate in previous syntheses of 1.