722508-56-7

Basic information

• Product Name: N-(N-trityl-L-prolinamido)-2-seleno-1,3,2-oxathiaphospholane
• Synonyms: N-(N-trityl-L-prolinamido)-2-seleno-1,3,2-oxathiaphospholane
• CAS NO: 722508-56-7
• Molecular Weight: 541.512
• Mol File: 722508-56-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(N-trityl-L-prolinamido)-2-seleno-1,3,2-oxathiaphospholane(CAS DataBase Reference)
• NIST Chemistry Reference: N-(N-trityl-L-prolinamido)-2-seleno-1,3,2-oxathiaphospholane(722508-56-7)
• EPA Substance Registry System: N-(N-trityl-L-prolinamido)-2-seleno-1,3,2-oxathiaphospholane(722508-56-7)

Safety Data

• Hazardous Substances Data: 722508-56-7(Hazardous Substances Data)

Upstream product

• 20354-32-9 2-chloro-1,3,2-oxathiaphospholane 
• 82935-40-8 (S)-(-)-1-trityl-2-pyrrolidinecarboxamide 

Relevant articles and documents

New approach to preparation of N-acylphosphoramido(thio)(seleno)ates

N-[2-(X)-1,3,2-Oxathiaphospholane] derivatives (X=S, Se, O) of carboxamides were prepared and their DBU-assisted reaction with alcohols led to the corresponding O-alkyl-N-acylphosphoramido(thio)(seleno)ates. Their structures were confirmed by MS analysis and 1H and 31P NMR spectroscopy. Independently N-acylphosphoramidoselenoates were converted to N-acylphosphoramidates by treatment with tert-butylperoxytrimethylsilane. The oxathiaphospholane approach was also applied to the synthesis of derivatives having N-prolylphosphoramido(thio)(seleno)ate linkages on the 5′-OH group of AMP.