72252-90-5 Usage
Uses
Used in Research Applications:
MEOSUC-ALA-ALA-PRO-VAL-AMC is used as a fluorogenic substrate for the quantification of human leukocyte and porcine pancreatic elastase. It allows researchers to study the activity and regulation of elastase enzymes, which are involved in various physiological processes and have been implicated in several diseases, including emphysema, cystic fibrosis, and cancer.
Used in Diagnostic Applications:
MEOSUC-ALA-ALA-PRO-VAL-AMC is used as a substrate in elastase assays using bone marrow lysates and pancreatic lysates. This allows for the detection and measurement of elastase activity in these tissues, which can be useful in diagnosing and monitoring diseases associated with elastase dysregulation, such as pancreatic diseases and certain types of cancer.
Used in Pharmaceutical Industry:
MEOSUC-ALA-ALA-PRO-VAL-AMC is used as a tool in drug discovery and development for the identification and optimization of elastase inhibitors. These inhibitors can be potential therapeutic agents for the treatment of diseases where elastase activity is a contributing factor, such as inflammatory conditions and certain types of cancer.
Biochem/physiol Actions
Km = 140 μM; kcat/Km = 120,000 M?1 s?1as substrates for human leukocyte and porcine pancreatic elastase
Check Digit Verification of cas no
The CAS Registry Mumber 72252-90-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,2,5 and 2 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 72252-90:
(7*7)+(6*2)+(5*2)+(4*5)+(3*2)+(2*9)+(1*0)=115
115 % 10 = 5
So 72252-90-5 is a valid CAS Registry Number.
InChI:InChI=1/C31H41N5O9/c1-16(2)27(30(42)34-20-9-10-21-17(3)14-26(39)45-23(21)15-20)35-29(41)22-8-7-13-36(22)31(43)19(5)33-28(40)18(4)32-24(37)11-12-25(38)44-6/h9-10,14-16,18-19,22,27H,7-8,11-13H2,1-6H3,(H,32,37)(H,33,40)(H,34,42)(H,35,41)
