72252-96-1

Basic information

• Product Name: N-succinimidyl-4-((iodoacetyl)amino)benzoate
• Synonyms: N-succinimidyl-(4-iodoacetamido)benzoate;N-[4-[[(2,5-Dioxopyrrolidin-1-yl)oxy]carbonyl]phenyl]-2-iodoacetamide;4-[(2-Iodoacetyl)aMino]benzoic Acid 2,5-dioxo-1-pyrrolidinyl Ester
• CAS NO: 72252-96-1
• Molecular Formula: C13H11IN2O5
• Molecular Weight: 402.14
• Product Categories: Cross Linking Reagents;MTS & Sulfhydryl Active Reagents
• Mol File: 72252-96-1.mol
• Article Data: 0

Chemical Properties

• Melting Point: 19-7-200°C (dec.)
• Boiling Point: 717.571°C at 760 mmHg
• Flash Point: 387.773°C
• Appearance: /
• Density: 1.87±0.1 g/cm3(Predicted)
• Vapor Pressure: 0mmHg at 25°C
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• PKA: 12.16±0.70(Predicted)
• CAS DataBase Reference: N-succinimidyl-4-((iodoacetyl)amino)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: N-succinimidyl-4-((iodoacetyl)amino)benzoate(72252-96-1)
• EPA Substance Registry System: N-succinimidyl-4-((iodoacetyl)amino)benzoate(72252-96-1)

Safety Data

• Hazardous Substances Data: 72252-96-1(Hazardous Substances Data)

Usage

Description

N-succinimidyl-4-((iodoacetyl)amino)benzoate is a heterobifunctional protein crosslinking reagent that contains both sulfhydryl and amino reactive groups. It is characterized by a spacer arm of 10.6 angstroms, which allows for the efficient and specific conjugation of proteins through the formation of stable covalent bonds.

Uses

Used in Biochemistry Research:
N-succinimidyl-4-((iodoacetyl)amino)benzoate is used as a protein crosslinking agent for the study of protein-protein interactions, protein structure, and function in biochemical research. Its sulfhydryl and amino reactive groups enable the specific labeling and modification of proteins, facilitating the investigation of their properties and interactions.
Used in Drug Development:
N-succinimidyl-4-((iodoacetyl)amino)benzoate is used as a protein conjugation reagent in the development of novel therapeutic agents. Its ability to form stable covalent bonds with proteins allows for the creation of targeted drug delivery systems, improving the efficacy and specificity of drug treatments.
Used in Diagnostic Applications:
N-succinimidyl-4-((iodoacetyl)amino)benzoate is used as a protein labeling agent in the development of diagnostic tools and assays. Its reactive groups enable the attachment of reporter molecules, such as fluorescent dyes or enzymes, to proteins, allowing for the sensitive and specific detection of target proteins in biological samples.
Used in Materials Science:
N-succinimidyl-4-((iodoacetyl)amino)benzoate is used as a protein immobilization reagent in the fabrication of biomaterials and biosensors. Its ability to form stable covalent bonds with proteins allows for the attachment of biologically active molecules to various surfaces, enabling the development of advanced materials with specific functions and properties.

InChI:InChI=1/C13H11IN2O5/c14-6-10(17)15-7-1-2-8(13(20)21)9(5-7)16-11(18)3-4-12(16)19/h1-2,5H,3-4,6H2,(H,15,17)(H,20,21)/p-1