722544-24-3

Upstream product

• 174891-10-2 (5-amino-2H-pyrazol-3-yl)acetic acid 
• 288383-86-8 7-(benzyloxy)-4-chloroquinazoline 
• 16499-57-3 7-fluoro-3H-quinazolin-4-one 
• 193002-14-1 7-(benzyloxy)quinazolin-4(3H)-one 

Relevant academic research and scientific papers

As Aurora kinase inhibitors of the substituted quinazoline derivatives

The invention relates to a substituted quinazoline derivative as an aurora kinase inhibitor, which is shown as structural formula (I) or (Ia), tautomers, hydrates, solvates or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the tautomers, hydrates, solvates and pharmaceutically acceptable salts as drug active ingredients, and application of the compounds and the pharmaceutical compositions in preparation of medicines for protection, treatment, curing or alleviation of proliferative diseases of patients.

PHOSPHONOOXY QUINAZOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE

Quinazoline derivatives of formula (I) wherein A is 5-membered heteroaryl containing a nitrogen atom and one or two further nitrogen atoms; compositions containing them, processes for their preparation and their use in therapy.