72255-86-8

Basic information

• Product Name: 2,5-dibromo-1-methyl-4-nitroimidazole
• CAS NO: 72255-86-8
• Molecular Weight: 284.895
• Mol File: 72255-86-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,5-dibromo-1-methyl-4-nitroimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-dibromo-1-methyl-4-nitroimidazole(72255-86-8)
• EPA Substance Registry System: 2,5-dibromo-1-methyl-4-nitroimidazole(72255-86-8)

Safety Data

• Hazardous Substances Data: 72255-86-8(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 6154-30-9 2,4⁽⁵⁾-dibromo-5⁽⁴⁾-nitroimidazole 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 16681-63-3 2-bromo-1-methyl-4-nitroimidazole 

Relevant articles and documents

Nucleophilic substitution studies on nitroimidazoles, and applications to the synthesis of biologically active compounds

The rationalization of the synthesis of substituted analogs of megazol, a biologically active 5-nitroimidazole at position 4 of the imidazole ring, had led to the study of intermediate steps. The methylation by diazomethane of 2,4-(5)dihalogeno-5-(4)nitroimidazole is regioselective leading to 2,4- dihalogeno-1-methyl-5-nitroimidazole 2. On this compound 2, hard nucleophiles such as cyanide, methoxide or hydride anions react only with the halogen at the 2 position; whereas soft nucleophiles such as amine, thiol or trifluoromethyl anion from an organocopper species react only with the halogen at position 4 in the intermediate 3b or compound 4b.