7226-75-7

Basic information

• Product Name: 5-benzyloxymethyl-3',5'-di-O-toluoyl-2'-deoxyuridine
• Synonyms: 5-benzyloxymethyl-3',5'-di-O-toluoyl-2'-deoxyuridine
• CAS NO: 7226-75-7
• Molecular Weight: 584.626
• Mol File: 7226-75-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-benzyloxymethyl-3',5'-di-O-toluoyl-2'-deoxyuridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-benzyloxymethyl-3',5'-di-O-toluoyl-2'-deoxyuridine(7226-75-7)
• EPA Substance Registry System: 5-benzyloxymethyl-3',5'-di-O-toluoyl-2'-deoxyuridine(7226-75-7)

Safety Data

• Hazardous Substances Data: 7226-75-7(Hazardous Substances Data)

Upstream product

• 4330-34-1 methyl 3,5-di-O-toluoyl-2-deoxy-D-ribofuranose 
• 98808-20-9 O,O'-bis(trimethylsilyl)-5-benzyloxymethyluracil 

Downstream Products

• 19083-35-3 5-(benzyloxy)methyl-2′-deoxyuridine 
• 304849-85-2 5-[(benzyloxy)methyl]-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine 
• 304849-87-4 5-benzyloxymethyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine 3'-(N,N-diisopropyl)-2-cyanoethyl phosphoramidite 

Relevant articles and documents

Preparation of oligodeoxynucleotides containing 5-(N-methylpiperazinyl) and 5-benzyloxymethyl uracils

Deprotected compounds 1 and 9 were allowed to react with 4,4'-dimethoxytrityl chloride in pyridine to give 5'-O-DMT nucleosides 2 and 10. The 3'-phosphoramidites 4 and 11 were incorporated into oligodeoxynucleosides (ODNs). The hybridization properties of the modified ODNs with their complementary DNA strands were studied. Interesting results were obtained when 11 was inserted as a bulged nucleoside into TWAs, duplexes, and triplexes.