Conglobatin, a macrolide dilactone isolated from Streptomyces conglobatus, features an unusual dimeric structure with pendant oxazole groups. It demonstrates potent biological activity with an IC50 of 0.63 μg/ml in a NFAT-dependent transcription assay and shows no toxicity at doses up to 1000 mg/kg when administered to mice either orally or interperitoneally.
72263-05-9
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Basic information
- Product Name: CONGLOBATIN
- Synonyms: CONGLOBATIN;(3E,5R,7S,8S,11E,13R,15S,16S)-3,5,7,11,13,15-Hexamethyl-8,16-bis(5-oxazolylmethyl)-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione;FW-04-806;Conglobatin, >=99%
- CAS NO:72263-05-9
- Molecular Formula: C28H38N2O6
- Molecular Weight: 498.61
- EINECS: N/A
- Product Categories: Antibiotic
- Mol File: 72263-05-9.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 673.4 °C at 760 mmHg
- Flash Point: 361.1 °C
- Appearance: White to off-white solid.
- Density: 1.060±0.06 g/cm3 (20 ºC 760 Torr)
- Vapor Pressure: 5.37E-18mmHg at 25°C
- Refractive Index: 1.484
- Storage Temp.: ?20°C
- Solubility: N/A
- CAS DataBase Reference: CONGLOBATIN(CAS DataBase Reference)
- NIST Chemistry Reference: CONGLOBATIN(72263-05-9)
- EPA Substance Registry System: CONGLOBATIN(72263-05-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 72263-05-9(Hazardous Substances Data)
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72263-05-9 Usage
Uses
Used in Pharmaceutical Industry:Conglobatin is used as an anticancer agent for its ability to exhibit anticancer properties, making it a promising candidate for the development of novel cancer therapies.
Additionally, conglobatin is used as an immunosuppressant due to its immunosuppressive effects, which can be beneficial in managing autoimmune diseases and preventing transplant rejections.
Check Digit Verification of cas no
The CAS Registry Mumber 72263-05-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,2,6 and 3 respectively; the second part has 2 digits, 0 and 5 respectively.Calculate Digit Verification of CAS Registry Number 72263-05:
(7*7)+(6*2)+(5*2)+(4*6)+(3*3)+(2*0)+(1*5)=109
109 % 10 = 9
So 72263-05-9 is a valid CAS Registry Number.
InChI:InChI=1/C28H38N2O6/c1-17-7-19(3)25(11-23-13-29-15-33-23)35-28(32)22(6)10-18(2)8-20(4)26(12-24-14-30-16-34-24)36-27(31)21(5)9-17/h9-10,13-20,25-26H,7-8,11-12H2,1-6H3/b21-9-,22-10+/t17-,18-,19+,20+,25+,26+/m1/s1
72263-05-9Upstream product
72263-05-9Downstream Products
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CONGLOBATIN
