72265-52-2

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 112176-92-8 (+/-)-ethyl quinuclidine-2-carboxylate 
• 100-76-5 Quinuclidine 
• 90-96-0 bis(p-methoxyphenyl)methanone 
• 52601-23-7 quinuiclidine-2-carboxylic acid hydrochloride 
• 66073-49-2 quinuiclidine-2-carbonyl chloride hydrochloride 

Relevant academic research and scientific papers

Facile α-deprotunation-electrophilic substitution of quinuclidine and DABCO

Deprotonation of BF3 complexes of quinuclidine or DABCO by Schlosser base and subsequent reaction with electrophiles affords α-substituted products in moderate to good yields.

Mono- and diaryl-2-quinuclidinylcarbinols with local anesthetic and antiarrhythmic activity

The reaction between 2-carboethoxyquinuclidine and various aryl- and heteroaryllithium reagents gave mixtures of aryl 2-quinuclidinyl ketones and diaryl-2-quinuclidinylcarbinols. Diborane reduction of the ketones gave the erythro-carbinols, stereochemically analogous to quinidine. Several of the mono- and diarylcarbinols exhibited potent local anesthetic and antiarrhythmic activity, in some cases greater than that of quinidine. Diphenyl-2-quinuclidinylcarbinol and a (bromomethoxyphenyl)(methoxyphenyl)-2-quinuclidinylcarbinol were particularly active in reverting ouabain-induced arrhythmia in dogs, showing a potency and duration of action equal to or greater than that of propranolol.