72279-16-4

Upstream product

• 90-02-8 salicylaldehyde 
• 22192-22-9 C₂₅H₂₁Cl₂P 
• 72398-88-0 2-[(Z)-2-(2-Chloro-phenyl)-vinyl]-phenol 
• 110-52-1 1,4-dibromo-butane 
• 107776-75-0 2-[2-(2-chlorophenyl)ethyl]phenol 

Downstream Products

• 72284-46-9 2-(4-dimethylaminobutoxy)-2'-chlorobibenzyl hydrochloride 
• 127003-30-9 2-(4-dimethylaminobutoxy)-2'-chlorobibenzyl 

Relevant academic research and scientific papers

Syntheses and Platelet Aggregation Inhibitory and Antithrombotic Properties of ethyl>benzenes

A series of ethyl>benzene derivatives were synthesized and evaluated for their ability to inhibit collagen-induced platelet aggregation in vitro and to protect experimantal thrombosis in mice.The results showed that the compounds were in vitro inhibitors of collagen-induced platelet aggregation.Most of them were also effective in the mouse antithrombotic assay.The compounds were found to be potent antagonists to S2 serotonergic receptor, and good correlation (r = 0.85) between their S2 serotonergic receptor antagonism and their potency as platelet antiaggregatory drugs was observed.Among the compounds studied, monophenoxy>methyl>ethyl>succinate hydrochloride (12b, MCI-9042) was selected for further pharmacological and toxicological evaluation.