72290-28-9

Usage

Uses

Used in Agricultural Applications:
2,6-dichloro-3-(aminosulfonyl)benzoic acid is used as a selective herbicide for controlling a variety of broadleaf and grassy weeds in crops such as soybeans, sunflowers, and potatoes. It is applied for its ability to inhibit the enzyme acetolactate synthase, which is essential for the synthesis of branched-chain amino acids in plants, leading to the effective control of unwanted vegetation without causing significant harm to the target crops.
The use of Amidosulfuron in agriculture is particularly beneficial due to its low toxicity to mammals, which ensures the safety of both humans and livestock when used according to recommended guidelines. Moreover, its effectiveness at low application rates contributes to its cost-efficiency and reduced environmental impact compared to other, more toxic herbicides. However, it is crucial to use this chemical compound responsibly, following best practices to minimize any potential adverse effects on the environment and non-target species.

Upstream product

• 50-30-6 2,6-dichlorobenzoic acid 
• 53553-05-2 3-(chlorosulfonyl)-2,6-dichlorobenzoic acid 

Downstream Products

• 1259931-80-0 C₄₀H₄₀Cl₂F₂N₆O₄S 
• 72290-02-9 2-Benzylamino-6-chloro-N-phenethyl-3-sulfamoyl-benzamide 
• 72290-01-8 2-Benzylamino-6-chloro-3-sulfamoyl-N-o-tolyl-benzamide 
• 72290-09-6 6-Chloro-2-(2-ethoxy-ethylamino)-N-phenethyl-3-sulfamoyl-benzamide 
• 72290-30-3 2-Chloro-6-(2-hydroxy-ethylamino)-3-sulfamoyl-N-o-tolyl-benzamide 
• 72290-49-4 2-Butylamino-6-chloro-3-sulfamoyl-N-o-tolyl-benzamide 
• 72290-14-3 6-Chloro-2-(2-hydroxy-ethylamino)-3-sulfamoyl-N-o-tolyl-benzamide 
• 72290-10-9 6-Chloro-N-(2-diethylamino-ethyl)-2-(2-ethoxy-ethylamino)-3-sulfamoyl-benzamide 
• 72290-04-1 2-Butylamino-6-chloro-N-phenethyl-3-sulfamoyl-benzamide 
• 72290-05-2 2-Butylamino-6-chloro-N-(2-diethylamino-ethyl)-3-sulfamoyl-benzamide 
• 72290-11-0 6-Chloro-2-(2-ethoxy-ethylamino)-N-(2-methoxy-ethyl)-3-sulfamoyl-benzamide 
• 72290-07-4 2-Butylamino-6-chloro-N-(2-methoxy-ethyl)-3-sulfamoyl-benzamide 
• 72289-99-7 2-Benzylamino-6-chloro-3-sulfamoyl-benzamide 
• 72290-12-1 6-Chloro-2-(2-ethylsulfanyl-ethylamino)-3-sulfamoyl-benzamide 

Relevant academic research and scientific papers

Novel 4,4-disubstituted piperidine-based C-C chemokine receptor-5 inhibitors with high potency against human immunodeficiency virus-1 and an improved human ether-a-go-go related gene (hERG) profile

We recently described (J. Med. Chem. 2008, 51, 6538-6546) a novel class of CCR5 antagonists with strong anti-HIV potency. Herein, we detail SAR converting leads 1 and 2 to druglike molecules. The pivotal structural motif enabling this transition was the secondary sulfonamide substituent. Further finetuning of the substituent pattern in the sulfonamide paved the way to enhancing potency and bioavailability and minimizing hERG inhibition, resulting in discovery of clinical compound 122 (GSK163929).

CCR5 ANTAGONISTS AS THERAPEUTIC AGENTS

The present invention relates to compounds of formula (I) or pharmaceutically acceptable derivatives thereof, useful in the treatment or prophylaxis of CCR5-related diseases and disorders, for example, in the inhibition of HIV replication, the prevention or treatment of an HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).