72291-55-5Relevant academic research and scientific papers
Multinuclear NMR studies and Ab initio structure calculations of hindered phencyclone Diels-Alder adducts from symmetrical cyclic dienophiles: Cyclohexene, vinylene carbonate, vinylene trithiocarbonate and two N-aryl maleimides
Callahan, Ronald,Ramirez III, Orlando,Rosmarion, Kerstin,Rothchild, Robert,Bynum, Kevin C.
, p. 889 - 898 (2005)
A series of hindered Diels-Alder adducts have been prepared from phencyclone, 1, with various unusual symmetrical cyclic dienophiles, including cyclohexene, 2a; vinylene carbonate, 2b; vinylene trithiocarbonate, 2c; and the N-aryl maleimides: N-(4-dimethy
Organotin(IV) derivatives of amide-based carboxylates: Synthesis, spectroscopic characterization, single crystal studies and antimicrobial, antioxidant, cytotoxic, anti-leishmanial, hemolytic, noncancerous, anticancer activities
Ahmad, Iftikhar,Zia-ur-Rehman,Waseem, Amir,Tariq, Muhammad,MacBeth, Cora,Bacsa, John,Venkataraman, Deepak,Rajakumar, Augustine,Ullah, Nazif,Tabassum, Saira
, (2020/02/11)
Four new triorganotin(IV) amide based carboxylates of general formula R3SnL1 and R3SnL2, where R = Me(1,3) and n-butyl (2,4), and L1= (Z)-4-(p-methoxyphenylamino)-4-oxo-2-butenoic acid (HL1
Potent Synergy between Spirocyclic Pyrrolidinoindolinones and Fluconazole against Candida albicans
Premachandra, Ilandari Dewage Udara Anulal,Scott, Kevin A.,Shen, Chengtian,Wang, Fuqiang,Lane, Shelley,Liu, Haoping,Van Vranken, David L.
, p. 1672 - 1686 (2015/10/06)
A spiroindolinone, (1S,3R,3aR,6aS)-1-benzyl-6′-chloro-5-(4-fluorophenyl)-7′-methylspiro[1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3,3′-1H-indole]-2′,4,6-trione, was previously reported to enhance the antifungal effect of fluconazole against Candida albicans. A diastereomer of this compound was synthesized, along with various analogues. Many of the compounds were shown to enhance the antifungal effect of fluconazole against C. albicans, some with exquisite potency. One spirocyclic piperazine derivative, which we have named synazo-1, was found to enhance the effect of fluconazole with an EC50 value of 300 pM against a susceptible strain of C. albicans and going as low as 2 nM against some resistant strains. Synazo-1 exhibits true synergy with fluconazole, with an FIC index below 0.5 in the strains tested. Synazo-1 exhibited low toxicity in mammalian cells relative to the concentrations required for antifungal synergy. Synergy from stereochemical complexity: An attempt to synthesize analogues of a known spiroindolinone led to a series of diastereomers. One spiroindolinone, termed synazo-1, was shown to exhibit potent activity (300 pM) against C. albicans in the presence of fluconazole. Synazo-1 is a true synergizer and was also highly active against some drug-resistant C. albicans strains.
