72299-58-2

Usage

Uses

Used in Pharmaceutical Synthesis:
(5-IODO-PYRIDIN-3-YL)-METHANOL is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its presence in the molecular structure allows for the creation of complex molecules with potential therapeutic properties.
Used in Organic Chemistry:
In the realm of organic chemistry, (5-IODO-PYRIDIN-3-YL)-METHANOL serves as a versatile building block for the assembly of intricate organic molecules. Its reactivity and structural features facilitate the development of novel compounds with diverse applications.
Used in Chemical Reactions and Transformations:
(5-IODO-PYRIDIN-3-YL)-METHANOL is employed as a reagent in numerous chemical reactions and transformations. The iodine atom in its structure contributes to its reactivity, making it suitable for a wide range of chemical processes.
Used in Drug Discovery and Development:
(5-IODO-PYRIDIN-3-YL)-METHANOL's potential in drug discovery and development is significant. Its unique structure and reactivity make it a promising candidate for the creation of new drugs with improved efficacy and selectivity.
Used in Research and Industrial Applications:
(5-IODO-PYRIDIN-3-YL)-METHANOL is an important chemical for both research and industrial purposes. Its versatility and potential applications in various fields underscore its value in advancing scientific knowledge and developing innovative products.

InChI:InChI=1/C6H6INO/c7-6-1-5(4-9)2-8-3-6/h1-3,9H,4H2

Upstream product

• 29681-44-5 5-bromo-3-pyridine carboxylic acid methyl ester 
• 37669-64-0 (5-bromopyridin-3-yl)methanol 

Relevant academic research and scientific papers

A Modular Synthesis of Teraryl-Based α-Helix Mimetics, Part 4: Core Fragments with Two Halide Leaving Groups Featuring Side Chains of Proteinogenic Amino Acids

Teraryl-based α-helix mimetics have proven to be useful compounds for the inhibition of protein-protein interactions (PPI). We have developed a modular and flexible approach for the synthesis of teraryl-based α-helix mimetics using a benzene core unit featuring two halide leaving groups of differentiated reactivity in the Pd-catalyzed cross-coupling used for teraryl assembly. The use of para-bromo iodoarene core fragments resolved the issue of hydrolysis during cross-coupling that was observed when using triflate as a leaving group. We report a complete set of para-bromoiodoarene core fragments decorated with side chains of all proteinogenic amino acids relevant for PPI (Ala, Arg, Asn, Asp, Cys, Gln, Glu, His, Ile, Leu, Lys, Met, Phe, Ser, Thr, Trp, Tyr and Val). In order to be compatible with general cross-coupling conditions, some of the nucleophilic side chains had to be provided in a protected form to serve as stable building blocks.

A Modular Synthesis of Teraryl-Based α-Helix Mimetics, Part 5: A Complete Set of Pyridine Boronic Acid Pinacol Esters Featuring Side Chains of Proteinogenic Amino Acids

Teraryl-based α-helix mimetics have proven to be useful compounds for the inhibition of protein-protein interactions (PPI). We have developed a modular and flexible approach for the synthesis of teraryl-based α-helix mimetics using pyridine containing boronic acid building blocks to increase the water solubility. Following our initial publication in which we have introduced the methodology in combination with sequential Pd-catalyzed cross-coupling for teraryl assembly, we can now report a complete set of pyridine based boronic acid building blocks decorated with side chains of all proteinogenic amino acids relevant for PPI (Ala, Arg, Asn, Asp, Cys, Gln, Glu, His, Ile, Leu, Lys, Met, Phe, Ser, Thr, Trp, Tyr, Val) to complement the core fragment set. For a representative set of teraryls we have studied the influence of the pyridine rings on the solubility of the assembled oligoarenes.