72305-01-2 Usage
Description
(propoxycarbonyl)phosphonic acid is a phosphonic acid derivative and an organophosphorus compound, characterized by a phosphorus atom bonded to three oxygen atoms and a carbon atom with a propoxy (propoxycarbonyl) group attached. Its unique chemical structure makes it significant for applications in organic synthesis, chemical research, pharmaceuticals, agrochemicals, and materials science.
Uses
Used in Organic Synthesis:
(propoxycarbonyl)phosphonic acid is used as a building block for the synthesis of various complex organic molecules, leveraging its unique structure and reactivity.
Used in Chemical Research:
It serves as a valuable compound for studying the properties and behavior of organophosphorus compounds, contributing to the advancement of chemical knowledge.
Used in Pharmaceutical Development:
(propoxycarbonyl)phosphonic acid is used as a key intermediate in the development of new pharmaceuticals, potentially leading to novel drugs with improved efficacy and safety profiles.
Used in Agrochemicals:
It is employed as a component in the creation of new agrochemicals, aiming to enhance crop protection and yield through innovative chemical solutions.
Used in Materials Science:
(propoxycarbonyl)phosphonic acid is utilized in the research and development of new materials with specific properties, such as those with enhanced stability or reactivity, for various industrial applications.
Check Digit Verification of cas no
The CAS Registry Mumber 72305-01-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,3,0 and 5 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 72305-01:
(7*7)+(6*2)+(5*3)+(4*0)+(3*5)+(2*0)+(1*1)=92
92 % 10 = 2
So 72305-01-2 is a valid CAS Registry Number.
72305-01-2Relevant articles and documents
Synthesis of esters of phosphonoformic acid and their antiherpes activity
Noren,Helgstrand,Johansson,Misiorny,Stening
, p. 264 - 270 (2007/10/02)
Aliphatic and aromatic mono-, di-, and triesters of phosphonoformic (foscarnet) were synthesized. The triesters were prepared by the Michaelis-Arbuzov reaction and were hydrolyzed to di- and monoesters. The compounds were tested for antiviral activity on isolated herpes simplex virus type 1 (HSV-1) DNA polymerase, in a HSV-1 plaque reduction assay, and on a cutaneous HSV-1 infection in guinea pigs. None of the esters inhibited the activity of isolated HSV-1 polymerases. Monoesters with a free carboxylic group and diesters with an aromatic carboxylic ester function were active against the cutaneous herpesa infection. Mono- and diesters with an aromatic phosphonic ester group also showed activity in the plaque-reduction assay. However, mono- and diesters with aliphatic carboxylic ester groups were inactive in all test systems. The results show that all three acidic groups of phosphonoformic acid must be free in order to get antiviral activity at the enzyme level. However, certain esters of this acid may be biotransformed to the acid itself to give antiherpes activity.
