72306-81-1Relevant academic research and scientific papers
Substrate-Specific Reduction Mechanisms for NADH Models. Reduction of N-Methylacridinium Iodide and α,α,α-Trifluoroacetophenone
Tanner, Dennis D.,Kharrat, Abdelmajid
, p. 1646 - 1650 (2007/10/02)
The reduction of α,α,α-trifluoroacetophenone by five N-substituted dihydronicotinamides (DHNAs) proceeds by a free radical chain process initiated by single electron transfer (SET).In dry acetonitrile the chain, whose propagation chain steps contain a SET-hydrogen atom transfer sequence, could be inhibited with m-dinitrobenzene or initiated by AIBN.Under the same reduction conditions methylacridinium iodide does not undergo homolytic chain reduction.The reduction of methylacridinium iodide by all five of the DHNAs followed clean second-order kinetics which wereconsistent with a bimolecular hydride transfer.Although a chain reaction involving solely cross termination can also follow second-order kinetics, no evidence could be obtained for either chain inhibition or initiation.The reduction mechanism followed by the NADH models appears to be substrate-specific and results reached from such model studies must be evaluated with some reservation.
Effect of Isotope Scrambling and Tunneling on the Kinetic and Product Isotope Effects for Reduced Nicotinamide Adenine Dinucleotide Model Hydride Transfer Reactions
Powell, Michael F.,Bruice, Thomas C.
, p. 7139 - 7149 (2007/10/02)
The rates and kinetic isotope effect for reaction of several dihydronicotinamides with N-methylacridinium ions (MAI) have been measured under conditions that eliminate the possibility of anomalous kinetic (kH/kD) and product (YH
