7232-21-5 Usage
Description
Metoclopramide is an orally bioavailable serotonin (5-HT) receptor 5-HT3 antagonist with Ki and IC50 values of 995 and 308 nM, respectively, in rat cortical membranes. It is also a dopamine D2 receptor antagonist (IC50 = 483 nM in rat brain synaptic membranes). Oral administration of metoclopramide inhibits emesis induced by cisplatin and apomorphine in ferrets and dogs with ED50 values of 6.17 and 0.45 mg/kg, respectively. Metoclopramide reversibly inhibits human acetylcholinesterase (AChE) isolated from the caudate nucleus (Kis = 9.3 and 82 μM for competitive and non-competitive inhibition, respectively). Formulations containing metoclopramide have been used as anti-emetic and antipsychotic agents.
Chemical Properties
White Solid
Uses
Different sources of media describe the Uses of 7232-21-5 differently. You can refer to the following data:
1. Antiemetic;5-HT3 antagonist
2. A D2DR inhibitor and an HTR3E inhibitor
3. Dopamine D2 receptor antagonist. Antiemetic.
Biochem/physiol Actions
D2 antagonist; 5-HT3 antagonist; antipsychotic; anti-emetic.
Clinical Use
Nausea and vomiting
Veterinary Drugs and Treatments
Metoclopramide has been used in veterinary species for both its
GI stimulatory and antiemetic properties. It has been used clinically
for gastric stasis disorders, gastroesophageal reflux,
to allow
intubation of the small intestine, as a general antiemetic (for parvovirus,
uremic gastritis, etc.), and an antiemetic to prevent or treat
chemotherapy-induced vomiting.
Drug interactions
Potentially hazardous interactions with other drugs
Ciclosporin: increased ciclosporin blood levels.
Metabolism
Metoclopramide undergoes first-pass hepatic metabolism.
It is excreted in the urine, about 85% of a dose
being eliminated in 72 hours, 20% as unchanged
metoclopramide and the remainder as sulfate or
glucuronide conjugates, or as metabolites. About 5% of a
dose is excreted in faeces via the bile.
Check Digit Verification of cas no
The CAS Registry Mumber 7232-21-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,2,3 and 2 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 7232-21:
(6*7)+(5*2)+(4*3)+(3*2)+(2*2)+(1*1)=75
75 % 10 = 5
So 7232-21-5 is a valid CAS Registry Number.
