72320-58-2

Usage

InChI:InChI=1/C19H19N3/c1-2-6-15(7-3-1)17-14-19(22-12-10-20-11-13-22)21-18-9-5-4-8-16(17)18/h1-9,14,20H,10-13H2

Upstream product

• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 85-99-4 2-acetamidobenzophenone 
• 5855-57-2 4-phenyl-2-quinolinone 
• 110-85-0 piperazine 
• 5855-56-1 2-chloro-4-phenylquinoline 

Downstream Products

• 97634-03-2 4-(ω-chloropropyl)-1-(4-phenyl-2-quinolyl)piperazine 
• 72320-59-3 2-(4-ethyl-1-piperazinyl)-4-phenylquinoline 
• 97634-05-4 2-<3<4<2-(4-phenylquinolyl)>-1-piperazinyl>propyl>-1,2,4-triazolo<4,3-a>pyridine-3<2H>-one 
• 76093-55-5 2-(4-butyl-piperazin-1-yl)-4-phenyl-quinoline 

Relevant academic research and scientific papers

Anti-peptic ulcer agent

Use of a compound of the formula: STR1 wherein R is hydrogen atom or ethyl group, or a pharmaceutically acceptable salt thereof for prophylaxis and/or treatment of peptic ulcer, and a method for prophylaxis and/or treatment of peptic ulcer disease which c

Design, Synthesis, and Pharmacological Activities of 2-Substituted 4-Phenylquinolines as Potential Antidepressant Drugs

This work represents the design, synthesis, and pharmacological testing of 4-phenylquinoline derivatives as potential antidepressants.Various modifications of substituents at the 2-position of the quinoline ring were tried, and two main series of derivatives were synthesized.In the first series, an open (dialkylamino)alkyl chain is linked to the 2-position of the quinoline ring by isosteres.The second approach involved the synthesis of a novel analogue of trazodone with a 4-phenylquinoline grouping replacing the chlorophenyl group of trazodone.The potential antidepressant activity of these new compounds has been demonstrated by their antagonism to the reserpine-induced hypothermia in mice.Both length of the side chain and isosteric displacements within the side chain affect the value of the ED50 obtained.Compounds having three atoms separating the terminal nitrogen from the quinoline ring were found to be more active than those with four atoms.The 2-thia derivatives were devoid of antidepressant activity.Replacement of the open side chain at the 2-position of the quinoline ring by piperazine or substituted piperazines resulted in new compounds that are slightly more potent than imipramine.

2-(4-Ethyl-1-piperazinyl)-4-phenylquinoline, process for preparation thereof, and composition thereof

2-(4-Ethyl-1-piperazinyl)-4-phenylquinoline and its pharmaceutically acceptable acid addition salts, which are useful as antidepressant agents in the treatment of depression or depressive state in mammals including humans, and processes for the preparatio