723263-83-0Relevant academic research and scientific papers
Stereoselective nucleophilic addition with a new chiral template and its application to the synthesis of optically active α-arylglycine derivatives
Tohma, Shigemitsu,Rikimaru, Kentaro,Endo, Atsushi,Shimamoto, Keiko,Kan, Toshiyuki,Fukuyama, Tohru
, p. 909 - 917 (2007/10/03)
Mannich-type reaction of phenols with iminolactone 4, readily prepared from commercially available phenylglycine, proceeded with high stereoselectivity to give α-arylglycine derivatives. The reaction was also applicable to other electron-rich aromatic compounds, arylboronic acids and other nucleophiles. Additionally, several Lewis acid-promoted addition reactions with iminolactone 4 were accomplished efficiently. These adducts could be converted readily to the corresponding optically active α-amino acid derivatives.
