723308-60-9Relevant academic research and scientific papers
Design, synthesis, and evaluation of naphthalene-sulfonamide antagonists of human CCR8
Jenkins, Tracy J.,Guan, Bing,Dai, Mingshi,Li, Gang,Lightburn, Thomas E.,Huang, Shan,Freeze, B. Scott,Burdi, Douglas F.,Jacutin-Porte, Swanee,Bennett, Robert,Chen, Weirong,Minor, Charles,Ghosh, Shomir,Blackburn, Christopher,Gigstad, Kenneth M.,Jones, Matthew,Kolbeck, Roland,Yin, Wei,Smith, Sean,Cardillo, Daniel,Ocain, Timothy D.,Harriman, Geraldine C.
, p. 566 - 584 (2008/04/18)
The design, synthesis, and structure-activity relationship development of naphthalene-derived human CCR8 antagonists is described. In vitro binding assay results of these investigations are reported, critical interactions of the antagonists with CCR8 are
CCR8 INHIBITORS
-
Page 38, (2008/06/13)
Disclosed are CCR8 inhibitors represented by Structural Formulas (I). The variables in Structural Formula (I) are described herein. Also disclosed are methods of treating a subject with a CCR8 mediated condition, especially asthma, by administering one of the disclosed CCR8 inhibitors to the subject.
CCR8 INHIBITORS
-
Page 33, (2008/06/13)
Disclosed is an inhibitor of CCR8 that is represented by Structural Formula (I). Also disclosed are pharmaceutical compositions comprising a pharmaceutically acceptable carrier or diluent and a CCR8 inhibitor represented by Structural Formula (I). Also disclosed is a method of treating inflammatory disorders in a subject by administering a CCR8 inhibitor to the subject.
