723334-98-3Relevant academic research and scientific papers
Acid catalysed methanolysis of 2,5-diazabicyclo[2.2.2]octane-3,6-diones: Scope and limitations
Verbist, Bie M. P.,Smets, Wim J.,De Borggraeve, Wim M.,Compernolle, Frans,Hoornaert, Georges J.
, p. 4371 - 4374 (2007/10/03)
The selective methanolysis of 2,5-diazabicyclo[2.2.2]octane-3,6-dione systems is a key step in a synthetic procedure leading to 4-amino-6-oxo-2- piperidinecarboxylate systems. This reaction seems to be primarily governed by steric hindrance caused by the substituents at the 1- and 4-bridgehead positions of the dione. In absence of bulky substituents the methanolysis is directed by the secondary or tertiary nature of the two lactam moieties.
