72334-06-6Relevant academic research and scientific papers
Copper-Catalysed Reactions of Penicillin Derivatives with t-Butyl Perbenzoate
Clark, Bruce M.,Easton Christopher J.,Watkins, Sharon K.
, p. 1065 - 1070 (2007/10/02)
The benzoyloxylation of penicillin derivatives at C5, on treatment with t-butyl perbenzoate in the presence of a copper catalyst, is facilitated by a phthalimido group at C6 when the substituents on the lactam ring are in the cis orientation, but hindered when the groups are trans substituted.In the absence of a C6 substituent, a competing reaction occurs in which the thiazolidine ring is cleaved.
