723340-91-8

Upstream product

• 763-32-6 2-methyl-1-buten-4-ol 
• 123-72-8 butyraldehyde 
• 108-24-7 acetic anhydride 
• 57094-41-4 4-methyl-2-propyltetrahydro-2H-pyran-4-ol 
• 723340-74-7 (3RS,5S)-3-methyloctane-1,3.5-triol 1-acetate 
• 723341-05-7 (3RS,5S)-3-methyloctane-1,3,5-triol 5-acetate 
• 723340-72-5 (3RS,5S)-3-methyloctane-1,3,5-triol 

Downstream Products

• 131766-73-9 (2R,4R)-tetrahydro-4-methyl-2-propyl-2H-pyran-4-ol acetate 

Relevant academic research and scientific papers

SYNTHESIS OF CHIRALLY ENRICHED 2,4-DISUBSTITUTED TETRAHYDROPYRAN-4-OL AND ITS DERIVATIVES

The present invention discloses a process for synthesis of chiral 2,4-disubstituted- tetrahydropyran-4-ol and its derivatives having a general formal (I) comprising of asymmetric reaction of an aliphatic aldehyde and a homoallylic alcohol in the presence of a chiral organocatalyst, and a fragrance and cosmetic composition containing chirally enriched molecules of the said general formula (I) prepared by the aforesaid process.

Solvent-free catalysed synthesis of tetrahydropyran odorants: The role of SiO2·p-TSA catalyst on the Prins-cyclization reaction

An efficient, green and solvent-free catalysed Prins-cyclization reaction based on the simple grinding of an aldehyde and a homoallylic alcohol in the presence of catalytic amount of p-TSA on silica gel is reported. By this protocol were synthesized tetrahydropyran odorants including commercial Florol? and Clarycet?, in one and two steps respectively.

Preparation of the Enantiomerically Enriched Isomers of the Odorous Cyclic Ethers Clarycet, Florol, and Rhubafuran by Enzymatic Catalysis

All the enantiomerically enriched stereoisomers of Clarycet (1), Florol (2), and Rhubafuran (3) were prepared by biocatalysis routes. Their absolute configurations were established, and their olfactory properties were fully evaluated.