723341-65-9Relevant academic research and scientific papers
Discovery of imidazole vinyl pyrimidines as a novel class of kinase inhibitors which inhibit Tie-2 and are orally bioavailable
Buttar, David,Edge, Mike,Emery, Steve C.,Fitzek, Martina,Forder, Cheryl,Griffen, Alison,Hayter, Barry,Hayward, Chris F.,Hopcroft, Philip J.,Luke, Richard W.A.,Page, Ken,Stawpert, John,Wright, Andy
scheme or table, p. 4723 - 4726 (2009/04/06)
Tie-2 is a receptor tyrosine kinase which is involved in angiogenesis and thereby growth of human tumours. The discovery and SAR of a novel class of imidazole-vinyl-pyrimidine kinase inhibitors, which inhibit Tie-2 in vitro is reported. Their synthesis wa
THERAPEUTIC AGENTS
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Page 50, (2010/02/07)
A compound of the Formula: (I) (A chemical formula should be inserted here-please see paper copy enclosed herewith) Formula: (I); for use as a Tie2 receptor tyrosine kinase inhibitor in a warm-blooded animal such as man.
