723341-87-5

Usage

Chemical class

Piperazines

Derivative

1-methyl-4-(4-aminocyclohexanol)piperazine

Structure

Methyl group at the 1 position, 4-(4-aminocyclohexanol) group at the 4 position

Usage

Pharmaceutical intermediate

Application

Synthesis of various drugs

Purpose

Development of medications for various medical conditions

Known for

Potential therapeutic benefits

Ongoing research

Potential treatment of certain diseases

Precaution

Handle with care to avoid health risks

Upstream product

• 109-01-3 1-methyl-piperazine 
• 16801-63-1 benzyl N-(4-oxocyclohexyl)carbamate 
• 179321-49-4 N-(tert-butoxycarbonyl)-4-aminocyclohexanone 

Downstream Products

• 724772-49-0 2-amino-N-[4-(4-methylpiperazin-1-yl)cyclohexyl]-4-[(E)-2-(6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)vinyl]pyrimidine-5-carboxamide 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF A PYRIMIDINO-DIAZEPINE DERIVATIVE

In one aspect, the invention relates to a process for preparing a compound of formula (XII), wherein PG is a protecting group, or a compound of formula (XI), comprising the steps of: (i) treating a compound of formula XIII, wherein PG is a protecting group, with N- methylpiperazine to form a compound of formula XII, wherein said compound of formula XII is in the form of a mixture of cis and trans isomers; (ii) combining the mixture formed in step (i) with an organic solvent and heating the solvent mixture so formed; (iii) isolating the trans-isomer of the compound of formula XII from the solvent mixture formed in step (ii); and (iv) optionally treating said trans-isomer of the compound of formula XII with an acid to form a compound of formula XI; and isolating said compound of formula XI. Further aspects of the invention relate to processes for preparing pyrimido-diazepinone derivatives using the above process and intermediates.

PYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS

The present invention relates to a compound of formula (VII)I, or a pharmaceutically acceptable salt or ester thereof, wherein: X is NR7; Y is O or N-(CH2)nR19; n is 1, 2 or 3; m is 1 or 2; R1 and Rs

THERAPEUTIC AGENTS

A compound of the Formula: (I) (A chemical formula should be inserted here-please see paper copy enclosed herewith) Formula: (I); for use as a Tie2 receptor tyrosine kinase inhibitor in a warm-blooded animal such as man.