72336-19-7Relevant academic research and scientific papers
Synthesis of an array of amides by aluminium chloride assisted cleavage of resin-bound esters
Barn, David R.,Morphy, J. Richard,Rees, David C.
, p. 3213 - 3216 (2007/10/03)
A new method for the synthesis of amino amides using Wang or Tentagel-PHB resins is described. The method uses aluminium chloride to promote the conversion of resin-bound benzylic esters to amides under ambient conditions. The reactions were monitored in 'real-time' using 13C gel phase NMR.
Quantitative structure-activity relationships for N-[(N',N'-disubstituted-amino)acetyl]arylamines for local anesthetic activity and acute toxicity
Heymans,Le Therizien,Godfroid,Bessin
, p. 184 - 193 (2007/10/02)
The synthesis and physicochemical properties of a series of N-[(N',N'-disubstituted-amino)acetyl]arylamines are described. A QSAR method is applied to local anesthetic activity and acute toxicity by means of a 'nonclassic' substituent variation involving a modification on both aryl and amino moieties. The choice of the different parameters (partition coefficient, pK(a), connectivity index, molar refraction, and molar volume) is discussed and their different methods of determination are described. Molar refraction is the parameter which explains best the variance of the local anesthetic activity, and the quadratic regression with MR leads to a 'a posteriori' synthesis of one compound with optimized activity. However, the partition coefficient is the most explicative parameter for intravenous toxicity.
