72340-25-1

Upstream product

• 55-21-0 benzamide 
• 608-31-1 2,6-Dichloroaniline 
• 100-47-0 benzonitrile 

Downstream Products

• 89646-96-8 (4R,5R)-1-(2,6-Dichloro-phenyl)-2,5-diphenyl-4,5-dihydro-1H-imidazol-4-ol 
• 89646-87-7 4-[1-(2,6-Dichloro-phenyl)-2,5-diphenyl-4,5-dihydro-1H-imidazol-4-yl]-morpholine 
• 82635-84-5 2-({[N¹-(2,6-Dichloro-phenyl)-benzimidoyl]-amino}-methylene)-malonic acid diethyl ester 
• 89069-68-1 3-(2,6-dichlorophenyl)-2-phenyl-4(3H)-pyrimidinone 
• 89069-85-2 3-(2,6-dichlorophenyl)-2,6-diphenyl-4(3H)-pyrimidinone 
• 63105-17-9 N-(2.6-Dichlorphenyl)-N'-phenylharnstoff 
• 82636-08-6 1-(2,6-Dichloro-phenyl)-6-oxo-2-phenyl-1,6-dihydro-pyrimidine-5-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Trimethylaluminium-mediated reaction of primary carboxamides with amines and indoles: A convenient synthesis of amidines and indole-3-acylimines

A simple, convenient and general method, exhibiting good functional group tolerance, is described for the synthesis of N- and N,N-disubstituted amidines by the reaction of primary carboxamides with amines mediated by trimethylaluminium (AlMe3).

Synthesis & Pharmacological Evaluation of Ethyl 3-Substituted-phenyl-2-methylmercapto/ phenyl/ methyl-4(3H)-pyrimidone-5-carboxylates

A number of ethyl 3-substituted-phenyl-2-methylmercapto/ phenyl/ methyl-4(3H)-pyrimidone-5-carboxylates (V) have been prepared by the reaction of amidines (III) with diethyl ethoxymethylenemalonate.In order to confirm the structure (V), ethyl 3-(2'-methylphenyl)-2-methylmercapto-4(3H)pyrimidone-5-carboxylate (103) has been transformed into the earlier synthesised 3-(2'-methylphenyl)-2-methylmercapto-4(3H)-pyrimidone (115) by decarboxylation of 3-(2'-methylphenyl)-2-methylmercapto-4(3H)-pyrimidone-5-carboxylic acid (114), obtained by the alkaline hydrolysis of 103.Someof these compounds have shown antiinflammatory, diuretic and antipassive cutaneous anaphylaxis activities.