72343-06-7

Upstream product

• 66-72-8 pyridoxal 
• 613-94-5 benzoic acid hydrazide 
• 65-22-5 pyridoxal hydrochloride 

Downstream Products

• 54-47-7 pyridoxal 5'-phosphate 

Relevant academic research and scientific papers

Design, synthesis and anti-tuberculosis activity of hydrazones and N-acylhydrazones containing vitamin B6 and different heteroaromatic nucleus

Background: The term vitamin B6 refers to a set of six compounds, pyridoxine,pyridoxal,and pyridoxamine and their phosphorylated forms, among which pyridoxal 5′-phosphate (PLP) is the most important and active form acting as a critical cofactor

Suzuki-Miyaura cross-coupling reaction of aryl bromides catalyzed by palladium(II) pyridoxal hydrazone complexes

The reaction of [PdCl2(PPh3)2] and substituted pyridoxal hydrazone ligands (H2L) in methanol under reflux afford a series of palladium ONO coordinated complexes with general formula [Pd(PPh3)L] (where

Dioxovanadium(V) complexes of ONO donor ligands derived from pyridoxal and hydrazides: Models of vanadate-dependent haloperoxidases

[VO(acac)2] reacts with H2L [H2L are the hydrazones H2pydx-inh (I), H2pydx-nh (II), or H 2pydx-bhz (III); pydx = pyridoxal, inh = isonicotinohydrazide, nh = nicotinohydrazide, bhz = benzohydrazide] in dry methanol to yield the oxovanadium(IV) complexes [VOL] (H2L = I: 1; H2L = II: 4) or [VO(pydx-bhz)]. These complexes, when exposed to air, convert into the corresponding dioxovanadium(V) complexes [VO2HL] (H2L = I: 2; H2L = II: 5; H2L = III: 7). Aqueous solutions of vanadate and the ligands at pH = 7.5 give rise to the formation of [K(H 2O)3][VO2(pydx-inh)] (3), [K(H 2O)2][VO2(pydx-nh)] (6) and [K(H 2O)2][VO2(pydx-bhz)] (8). Treatment of 6 and 8 with H2O2 generates the oxo(peroxo)vanadium complexes [VO(O2)L] (H2L = II: 9; H2L = III: 10). Complexes 9 and 10 are capable of transferring an oxo group to PPh3. Acidification of 8 with HCl afforded a hydroxo(oxo) complex. The crystal and molecular structures of ligand I and complex 3 have been solved by single-crystal X-ray diffraction. In the anion 3, the vanadium atom is in a distorted tetragonal-pyramidal environment (τ = 0.23). The K+ ion is coordinated to four water molecules (two of which bridge to a neighbouring K+ ion), the pyridine nitrogen atom of an isonicotinic moiety, the equatorial oxo group of the VO2+ fragment, and the alcoholic group of the pyridoxal moiety, which links adjacent layers in the three-dimensional lattice network. In the presence of KBr/H2O 2, the anionic complexes 3, 6 and 8 catalyse the oxidative bromination of salicylaldehyde in water to 5-bromosalicylaldehyde in ca. 40% yields with ca. 87% selectivity. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.

Method of inhibiting fibrosis with pyridoxal benzoyl hydrazone and analogs thereof

Methods of inhibiting fibrosis comprising administering certain pyridoxal benzoyl hydrazones or analogs thereof are disclosed. Preferred hydrazones are pyridoxal benzoyl hydrazone, 3-hydroxyisonicotinaldehyde benzoyl hydrazone and salicylaldehyde benzoyl hydrazone. The methods are useful in treating fibrosing disorders, including dermal fibrosing disorders, fibrosis of internal organs and fibrotic conditions of the eye.

ETUDE INFRAROUGE DU PYRIDOXAL ISONICOTINOYLE HYDRAZONE ET DE COMPOSES ANALOGUES

Infrared spectra have been obtained for pyridoxal isonicotinoyl hydrazone, pyridoxal benzoyl hydrazone, salicylaldehyde isonicotinoyl hydrazone and salicylaldehide benzoyl hydrazone.Vibrational assignements are proposed mainly in the 2000-1200 cm-1/

Studies on Biologically Active Acylhydrazones. Part 1. Acid-Base Equilibria and Acid Hydrolysis of Pyridoxal Aroylhydrazones and Related Compounds

A series of pyridoxal aroylhydrazones has been synthesized and their UV, IR and 1H NMR spectra studied.In neutral methanol these hydrazones exist in the enolimine form, while in aqueous solution (pH ca.7.0) they exist predominantly in the zwitterionic form in which the phenolic proton is transferred to the pyridine nitrogen.Their aqueous acid-base equilibria show three successive steps for which protonation constants have been determined.The different acidity constants are correlated with Hammett substituent constants.The acid hydrolysis reactions of these hydrazones have also been investigated and the attack of a water molecule on the protonated azomethine seems to be the rate-controlling step.The hydrolysis reactions of N-salicylidene- and N-benzylidene-benzoylhydrazines have been studied for comparison.

Synthesis of New Acylhydrazones as Iron-Chelating Compounds

Fourteen acylhydrazides have been condensed with three aromatic o-hydroxy aldehydes (pyridoxal, salicylaldehyde, and 2-hydroxy-1-naphthaldehyde) to give 42 acylhydrazones, of which 38 are new.These compounds complex iron and have shown varying abilities to promote the movement of iron across biological membranes.Their infrared and nuclear magnetic resonance spectra support the structures assigned to them.

New Dioxouranium(VI) Complexes with Tridentate Dibasic Schiff Bases Derived from Pyridoxal and Amines

Several new dioxouranium(VI) complexes wuth the tridentate dibasic schiff bases derived from pyridoxal and 2-aminoethanol, 2-aminoethanethiol, o-aminophenol, o-aminobenzyl alcohol, benzoyl hydrazide, salicyl hydrazide or o-aminobenzene sulphonic acid have