72357-52-9

Basic information

• Product Name: ((Z)-4-Iodo-1-phenyl-but-1-enyloxy)-trimethyl-silane
• CAS NO: 72357-52-9
• Molecular Weight: 346.283
• Mol File: 72357-52-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ((Z)-4-Iodo-1-phenyl-but-1-enyloxy)-trimethyl-silane(CAS DataBase Reference)
• NIST Chemistry Reference: ((Z)-4-Iodo-1-phenyl-but-1-enyloxy)-trimethyl-silane(72357-52-9)
• EPA Substance Registry System: ((Z)-4-Iodo-1-phenyl-but-1-enyloxy)-trimethyl-silane(72357-52-9)

Safety Data

• Hazardous Substances Data: 72357-52-9(Hazardous Substances Data)

Upstream product

• 16029-98-4 trimethylsilyl iodide 
• 3481-02-5 cyclopropyl phenyl ketone 

Relevant articles and documents

Enolate formation from cyclopropyl ketones via iodide-induced ring opening and its use for stereoselective aldol reaction

Treatment of cyclopropyl ketones with TiCl4-n-Bu4NI mixed reagent provides (Z)-titanium enolates which afford syn-α-iodethyl-β-hydroxyketones stereoselectively upon subsequent reaction with various aldehydes. The aldol adducts are cyclized into trans-acyltetrahydrofurans in good yield by active alumina. In contrast, the use of Et2AlI in place of TiCl4-n-Bu4NI provides the corresponding anti aldol adducts with high stereoselectivity. These methods can complementarily provide both syn and anti isomers of α-iodoethyl-β-hydroxyketones from cyclopropyl ketones and aldehydes.