72362-25-5

Upstream product

• 90706-43-7 [1-(2-Chloro-ethyl)-pyrrolidin-2-yl]-acetic acid ethyl ester 
• 107408-34-4 ethyl (E)-6-chloro-2-hexenoate 
• 5707-04-0 Phenylselenyl chloride 
• 73354-00-4 ethyl (+)-(2R)-2-formyloxy-2,3-dihydro-1H-pyrrolizine-7-carboxylate 
• 78175-08-3 ethyl 6-chloro-8β-pyrrolizidine-1α-carboxylate hydrochloride 
• 73354-01-5 ethyl (+)-2-(R)-2-hydroxy-2,3-dihydro-1H-pyrrolizine-7-carboxylate 
• 73354-03-7 ethyl (+)-6α-hydroxy-8β-pyrrolizidine-1α-carboxylate 
• 73353-98-7 (-)-(2S,4R)-N-formyl-4-formyloxyproline 
• 63527-08-2 ethyl (+)-8β-pyrrolizidine-1α-carboxylate 

Downstream Products

• 17958-41-7 (+)-supinidine 

Relevant academic research and scientific papers

A SHORT AND NOVEL SYNTHESIS OF THE PYRROLIZIDINE ALKALOIDS, (+/-)-SUPINIDINE AND (+/-)-TRACHELANTHAMIDINE

The effective and short syntheses of the pyrrolizidine alkaloids, (+/-)-trachelanthamidine (8) and (+/-)-supinidine (12) were described.

Synthesis of Optically Active Pyrrolizidine Bases

Regiospecific 1,3-dipolar cycloaddition of ethyl propiolate to the NO-diformyl derivative (1) of natural (-)-4-hydroxy-L-proline followed by stereospecific hydrogenation gave ethyl (+)-6α-hydroxy-β-pyrrolizidine-1α-carboxylate (4).Confirmation of the abso