72374-62-0Relevant academic research and scientific papers
Reductive coupling of aliphatic cyclic imides and ω-amidoesters with benzophenones by low-valent titanium: Synthesis of 5-diarylmethylene-1,5-dihydropyrrol-2-ones, 6-diarylmethyl-2-pyridones, and ω-(diarylmethylene)lactams
Kise, Naoki,Kinameri, Syn,Sakurai, Toshihiko
, p. 3553 - 3569 (2019)
The reductive coupling of cyclic imides and ω-amidoesters with benzophenones by Zn-TiCl4 in THF and subsequent acid-catalyzed dehydration gave 5-diarylmethylene-1,5-dihydropyrrol-2-ones A, 6-diarylmethyl-2-pyridones B, and ω-(diarylmethylene)lactams C. In a similar manner, 3-((benzyloxy)carbonyl)amino substituted A, B, and C were synthesized from the corresponding 3-((benzyloxy)carbonyl)amino cyclic imides and ω-((benzyloxy)carbonyl)amino-ω-amidoesters prepared from L-aspartic and L-glutamic acids. In addition, 4- and 5-((benzyloxy)carbonyl)amino substituted C were also obtained by the same procedures from 2-((benzyloxy)carbonyl)amino-ω-amidoesters prepared from L-asparagine and L-glutamine, respectively.
Reductive coupling of aliphatic cyclic imides with benzophenones by low-valent titanium
Kise, Naoki,Kinameri, Syn,Sakurai, Toshihiko
, p. 6944 - 6948 (2013)
The reductive coupling of aliphatic cyclic imides with benzophenones by Zn–TiCl4 in THF gave two- and four-electron reduced products selectively by controlling the reaction conditions. Although cyclic and acyclic products were formed as mixtures in most cases, cyclic dehydrated products could be selectively obtained by heating the product mixtures in the presence of cat. p-TsOH.
