72399-85-0

Usage

Physical state

Clear, colorless liquid

Odor

Pungent

Primary uses

Production of polyurethane foams, coatings, adhesives, and sealants

Chemical class

Diisocyanate

Reactivity

Highly reactive

Sensitization potential

Potent sensitizer

Health risks

Skin and respiratory irritation, asthma, and allergic reactions

Industrial applications

Used in manufacturing processes for various products due to its reactivity and properties

Upstream product

• 16419-41-3 N,N'-(propane-1,3-diyl)diformamide 

Downstream Products

• 73442-06-5 <5,5-Diphenyl-2-oxazolin-4-spiro-3'-(1'-pyrrolin)-2-yl>diphenylmethanol 

Relevant academic research and scientific papers

Hydrolysis of Aliphatic Bis-isonitriles in the Presence of a Polar Super Aryl-Extended Calix[4]pyrrole Container

We report binding studies of an octa-pyridinium super aryl-extended calix[4]pyrrole receptor with neutral difunctional aliphatic guests in water. The guests have terminal isonitrile and formamide groups, and the complexes display an inclusion binding geom

Reaction of Bidentate Isonitrile Ligands with Iron Carbonyls

Reaction of the bidentate isonitriles CN(CH2)nNC ( n =2, 3, 4, or 6) with (cp = η-cyclopentadienyl) yields exclusively 2> derivatives which are fluxional in solution and exist in three isomeric forms (bridged-bridged, bridged-terminal, and terminal-terminal with respect to the bonding mode of the bidentate isonitrile).The proportion of the isomers containing terminally bound isonitrile increases with the length of the alkyl chain.The complexes may be protonated to yield 2>2 salts (n = 2 or 6) and may be cleaved with I2 to give and 2nNC>> (n = 2 or 6).Reaction ofCN(CH2)nNC (n = 2 or 6 with or yields exclusively 2nNC>>

Synthesis with α-Metalated Isocyanides, XLIII. - Experiments with Lithiated α,ω-Alkylene Diisocyanides

1,2-Ethylene diisocyanide (4a) reacts with two equivalents of butyllithium (-100 deg C) to give 1,1-dilithio-1,2-ethylene diisocyanide (7) which with ketones yields the oxazines 11. - 1,3-Propylene diisocyanide (4b) reacts with one equivalent butyllithium (-70 deg C) to furnish 1-lithio-1,3-propylene diisocyanide (12) which cyclizes to afford 3-lithio-1-pyrrolin-3-yl isocyanide (14).With ketones, chlorotrimethylsilane, and epoxides 14 furnishes the compounds 17-19 and 21. - 1,4-Butylene diisocyanide (4c) reacts (-100 deg C) with one equivalent butyllithium to give 1-lithio-1,4-butylene diisocyanide (23), and with two equivalents to give 1,4-dilithio-1,4-butylene diisocyanide (28).Both compounds are thermolabile, but can be trapped by electrophils which react below -60 deg C.