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7-Aminoactinomycin D (7-AAD) is a fluorescent DNA dye that is commonly used for the detection or exclusion of non-viable cells in flow cytometric analysis, as it is generally excluded by live cells. It displays excitation spectra of 488, 546, and 578 nm and an emission spectrum of 650 nm. As 7-AAD is detected in the far red range of the spectrum, it exhibits minimal spectral overlap with commonly used probes, therefore it can be used in conjunction with probes such as FITC. 7-AAD has been used to evaluate apoptosis and cell-mediated cytotoxicity and to stain DNA in cells that have been fixed and permeabilized by a variety of methods.
Used in Biomedical Research:
7-Aminoactinomycin D is used as a fluorescent DNA stain for apoptosis research and flow cytometry studies. It aids in the detection and exclusion of non-viable cells, enabling researchers to evaluate apoptosis and cell-mediated cytotoxicity. Its unique spectral properties allow it to be used in combination with other probes, such as FITC, for more comprehensive analysis.

7240-37-1

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7240-37-1 Usage

Biochem/physiol Actions

Primary Targetleukemias and sarcomas

References

1) Telieps?et al.?(2013)?Cellular-FLIP, Raji isoform (c-FLIP R) modulates cell death induction upon T-cell activation and infection, Eur. J. Immunol. 43 1499 2) Schmid?et al.?(2007)?Live-cell assay for detection of apoptosis by dual-laser flow cytometry using Hoechst 33342 and 7-amino-actinomycin D, Nat. Protoc.?2?187 3) Toba?et al.?(2000) Cell kinetic study of normal human bone marrow hematopoiesis and acute leukemia using 7AAD/PY, Eur.J.Haematol. 64 10 4) Lecoeur?et al.?(1997)?Strategies for phenotyping apoptotic peripheral human lymphocytes comparing ISNT, annexin-V and 7-AAD cytofluorometric staining methods, J. Immunol. Methods?209?111 5) Su?et al.?(1996)?Hematopoietic cell protein-tyrosine phosphatase-deficient motheaten mice exhibit T cell apoptosis defect, J. Immunol.?156?4198

Check Digit Verification of cas no

The CAS Registry Mumber 7240-37-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,2,4 and 0 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 7240-37:
(6*7)+(5*2)+(4*4)+(3*0)+(2*3)+(1*7)=81
81 % 10 = 1
So 7240-37-1 is a valid CAS Registry Number.
InChI:InChI=1/C62H87N13O16/c1-26(2)42-59(85)74-21-17-19-36(74)57(83)70(13)24-38(76)72(15)48(28(5)6)61(87)89-32(11)44(55(81)66-42)68-53(79)34-23-35(63)30(9)51-46(34)65-47-40(41(64)50(78)31(10)52(47)91-51)54(80)69-45-33(12)90-62(88)49(29(7)8)73(16)39(77)25-71(14)58(84)37-20-18-22-75(37)60(86)43(27(3)4)67-56(45)82/h23,26-29,32-33,36-37,42-45,48-49H,17-22,24-25,63-64H2,1-16H3,(H,66,81)(H,67,82)(H,68,79)(H,69,80)

7240-37-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-aminoactinomycin D

1.2 Other means of identification

Product number -
Other names 2,7-diamino-4,6-dimethyl-3-oxo-1-N,9-N-bis[7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:7240-37-1 SDS

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